PMID- 26096167
OWN - NLM
STAT- MEDLINE
DCOM- 20161025
LR  - 20161230
IS  - 1532-4281 (Electronic)
IS  - 1079-9893 (Linking)
VI  - 36
IP  - 1
DP  - 2016
TI  - Potential signal pathway between all-trans retinoic acid and LMX1B in 
      hypoxia-induced renal tubular epithelial cell injury.
PG  - 53-6
LID - 10.3109/10799893.2015.1018434 [doi]
AB  - All-trans retinoic acid (ATRA), an active metabolite of vitamin A, exerts various 
      effects on physiological processes such as cell growth, differentiation, 
      apoptosis and inflammation. LMX1B, a developmental LIM-homeodomain transcription 
      factor, is widely expressed in vertebrate embryos, and it takes part in the 
      development of diverse structures such as limbs, kidneys, eyes, brains, etc. 
      Renal tubular epithelial cell culture was performed, and mRNA and protein 
      expression of some factors were detected. We recently demonstrated that ATRA 
      up-regulated the LMX1B, and down-regulated the transforming growth factor-beta1, 
      collagen IV and fibronectin in a hypoxia/reoxygenation (H-R) injury system in 
      renal tubular epithelial cells (RTEC). In conclusion, ATRA acts as a positive 
      regulator of LMX1B in H-R RTEC.
FAU - Zhou, Tian-Biao
AU  - Zhou TB
AD  - a Department of Nephrology , The Sixth Affiliated Hospital, Sun Yat-Sen 
      University , Guangzhou , P.R. China .
FAU - Ou, Chao
AU  - Ou C
AD  - b Department of Experimental Pathology , The Affiliated Tumor Hospital of Guangxi 
      Medical University , NanNing , P.R. China .
FAU - Jiang, Zong-Pei
AU  - Jiang ZP
AD  - a Department of Nephrology , The Sixth Affiliated Hospital, Sun Yat-Sen 
      University , Guangzhou , P.R. China .
FAU - Xiong, Meng-Ran
AU  - Xiong MR
AD  - a Department of Nephrology , The Sixth Affiliated Hospital, Sun Yat-Sen 
      University , Guangzhou , P.R. China .
AD  - c Department of Critical Care Medicine , and.
FAU - Zhang, Feng
AU  - Zhang F
AD  - a Department of Nephrology , The Sixth Affiliated Hospital, Sun Yat-Sen 
      University , Guangzhou , P.R. China .
AD  - d Department of Respiration , The Sixth Affiliated Hospital, Sun Yat-Sen 
      University , Guangzhou , P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150622
PL  - England
TA  - J Recept Signal Transduct Res
JT  - Journal of receptor and signal transduction research
JID - 9509432
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Collagen Type IV)
RN  - 0 (LIM homeobox transcription factor 1 beta)
RN  - 0 (LIM-Homeodomain Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - Apoptosis/drug effects
MH  - Blotting, Western
MH  - Cell Differentiation/drug effects
MH  - Cell Hypoxia/*drug effects
MH  - Cell Proliferation/drug effects
MH  - Cells, Cultured
MH  - Collagen Type IV/genetics/metabolism
MH  - Epithelial Cells/drug effects/metabolism/*pathology
MH  - Kidney Tubules/drug effects/injuries/metabolism/*pathology
MH  - LIM-Homeodomain Proteins/genetics/*metabolism
MH  - Oxidative Stress/drug effects
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Real-Time Polymerase Chain Reaction
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Signal Transduction/drug effects
MH  - Transcription Factors/genetics/*metabolism
MH  - Transforming Growth Factor beta1/genetics/metabolism
MH  - Tretinoin/*pharmacology
OTO - NOTNLM
OT  - All-trans retinoic acid
OT  - LMX1B
OT  - extracellular matrix
OT  - renal tubular epithelial cell
OT  - transforming growth factor-beta1
EDAT- 2015/06/23 06:00
MHDA- 2016/10/26 06:00
CRDT- 2015/06/23 06:00
PHST- 2015/06/23 06:00 [entrez]
PHST- 2015/06/23 06:00 [pubmed]
PHST- 2016/10/26 06:00 [medline]
AID - 10.3109/10799893.2015.1018434 [doi]
PST - ppublish
SO  - J Recept Signal Transduct Res. 2016;36(1):53-6. doi: 
      10.3109/10799893.2015.1018434. Epub 2015 Jun 22.