PMID- 26096341
OWN - NLM
STAT- MEDLINE
DCOM- 20160531
LR  - 20201209
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 Jun 22
TI  - Association between interleukin-18 gene polymorphism and Helicobacter pylori 
      infection in the Korean population.
PG  - 11535
LID - 10.1038/srep11535 [doi]
LID - 11535
AB  - Interleukin-18 (IL-18) is a pleiotropic, pro-inflammatory cytokine that is 
      capable of promoting the Th1 response. A predominant Th1 response induces chronic 
      and persistent inflammatory changes in the gastric mucosa in response to 
      Helicobacter pylori (H. pylori) infection. The aim of this study was to 
      investigate the potential association between IL-18 gene polymorphisms and 
      susceptibility to H. pylori infection in the Korean population. A total of 678 
      subjects who underwent a routine health check-up were enrolled. The IL-18 gene 
      polymorphisms at positions -656, -607, -137, +113, and +127 were genotyped. H. 
      pylori positivity was demonstrated in 456 subjects (67.3%). The allele 
      frequencies of IL-18 gene polymorphisms at position -137 (rs187238) were 
      different based on the status of H. pylori infection (G vs. C, adjusted OR 0.64 
      CI: 0.47-0.87, P = 0.005). The results indicate that the genetic variants in the 
      IL-18 gene may be associated with susceptibility to H. pylori infection in the 
      Korean population, suggesting that IL-18 plays a role in the pathogenesis of H. 
      pylori-associated diseases. However, this finding requires further replication 
      and validation.
FAU - Myung, Dae-Seong
AU  - Myung DS
AD  - Department of Internal Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
FAU - Lee, Wan-Sik
AU  - Lee WS
AD  - Department of Internal Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
FAU - Park, Young-Lan
AU  - Park YL
AD  - Department of Internal Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
FAU - Kim, Nuri
AU  - Kim N
AD  - Department of Internal Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
FAU - Oh, Hyung-Hoon
AU  - Oh HH
AD  - Department of Internal Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
FAU - Kim, Mi-Young
AU  - Kim MY
AD  - Department of Internal Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
FAU - Oak, Chan-Young
AU  - Oak CY
AD  - Department of Internal Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
FAU - Chung, Cho-Yun
AU  - Chung CY
AD  - Department of Internal Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
FAU - Park, Hyung-Chul
AU  - Park HC
AD  - Department of Internal Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
FAU - Kim, Jong-Sun
AU  - Kim JS
AD  - Department of Internal Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
FAU - Cho, Sung-Bum
AU  - Cho SB
AD  - Department of Internal Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
FAU - Kweon, Sun-Seog
AU  - Kweon SS
AD  - Department of Preventive Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
FAU - Joo, Young-Eun
AU  - Joo YE
AD  - Department of Internal Medicine, Chonnam National University Medical School, 
      Gwangju, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150622
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Gene Frequency/genetics
MH  - *Genetic Predisposition to Disease
MH  - Helicobacter Infections/*genetics
MH  - *Helicobacter pylori
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Republic of Korea
MH  - Young Adult
PMC - PMC4476145
EDAT- 2015/06/23 06:00
MHDA- 2016/06/01 06:00
PMCR- 2015/06/22
CRDT- 2015/06/23 06:00
PHST- 2014/09/18 00:00 [received]
PHST- 2015/05/07 00:00 [accepted]
PHST- 2015/06/23 06:00 [entrez]
PHST- 2015/06/23 06:00 [pubmed]
PHST- 2016/06/01 06:00 [medline]
PHST- 2015/06/22 00:00 [pmc-release]
AID - srep11535 [pii]
AID - 10.1038/srep11535 [doi]
PST - epublish
SO  - Sci Rep. 2015 Jun 22;5:11535. doi: 10.1038/srep11535.