PMID- 26097435 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150623 LR - 20220311 IS - 1478-7954 (Print) IS - 1478-7954 (Electronic) IS - 1478-7954 (Linking) VI - 13 DP - 2015 TI - Level of agreement between patient-reported EQ-5D responses and EQ-5D responses mapped from the SF-12 in an injury population. PG - 14 LID - 10.1186/s12963-015-0047-z [doi] LID - 14 AB - BACKGROUND: Comparing health-related quality of life (HRQL) outcomes between studies is difficult due to the wide variety of instruments used. Comparing study outcomes and facilitating pooled data analyses requires valid "crosswalks" between HRQL instruments. Algorithms exist to map 12-item Short Form Health Survey (SF-12) responses to EQ-5D item responses and preference weights, but none have been validated in populations where disability is prevalent, such as injury. METHODS: Data were extracted from the Validating and Improving injury Burden Estimates Study (Injury-VIBES) for 10,166 adult, hospitalized trauma patients, with both the three-level EQ-5D (EQ-5D-3L) and SF-12 data responses at six and 12-months postinjury. Agreement between actual (patient-reported) and estimated (mapped from SF-12) EQ-5D-3L item responses and preference weights was assessed using Kappa, Prevalence-Adjusted Bias-Adjusted Kappa statistics and Bland-Altman plots. RESULTS: Moderate agreement was observed for usual activities, pain/discomfort, and anxiety/depression. Agreement was substantial for mobility and self-care items. The mean differences in preference weights were -0.024 and -0.012 at six and 12 months (p < 0.001), respectively. The Bland-Altman plot limits of agreement were large compared to the range of valid preference weight values (-0.56 to 1.00). Estimated EQ-5D-3L responses under-reported disability for all items except pain/discomfort. CONCLUSIONS: Caution should be taken when using EQ-5D-3L responses mapped from the SF-12 to describe patient outcomes or when undertaking economic evaluation, due to the underestimation of disability associated with mapped values. The findings from this study could be used to adjust expected EQ-5D-3L preference weights when estimated from SF-12 item responses when combining data from studies that use either instrument. FAU - Gabbe, Belinda J AU - Gabbe BJ AD - Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia ; Centre for Improvement of Population Health through E-records Research, Swansea University, Swansea, UK. FAU - McDermott, Emma AU - McDermott E AD - Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. FAU - Simpson, Pam M AU - Simpson PM AD - Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. FAU - Derrett, Sarah AU - Derrett S AD - Injury Prevention Research Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand ; School of Health and Social Services, Massey University, Palmerston North, New Zealand. FAU - Ameratunga, Shanthi AU - Ameratunga S AD - Section of Epidemiology and Biostatistics, School of Population Health, University of Auckland, Auckland, New Zealand. FAU - Polinder, Suzanne AU - Polinder S AD - Department of Public Health, Erasmus MC, Rotterdam, The Netherlands. FAU - Lyons, Ronan A AU - Lyons RA AD - Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia ; Centre for Improvement of Population Health through E-records Research, Swansea University, Swansea, UK ; Public Health Wales NHS Trust, Swansea, Wales UK. FAU - Rivara, Frederick P AU - Rivara FP AD - Departments of Pediatrics and Epidemiology, and the Harborview Injury Prevention and Research Center, University of Washington, Seattle, USA. FAU - Harrison, James E AU - Harrison JE AD - Research Centre for Injury Studies, Flinders University, Adelaide, South Australia. LA - eng GR - MR/K006525/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article DEP - 20150613 PL - England TA - Popul Health Metr JT - Population health metrics JID - 101178411 PMC - PMC4474565 OTO - NOTNLM OT - Agreement OT - EQ-5D OT - Injury OT - Quality of life OT - SF-12 EDAT- 2015/06/23 06:00 MHDA- 2015/06/23 06:01 PMCR- 2015/06/13 CRDT- 2015/06/23 06:00 PHST- 2014/07/23 00:00 [received] PHST- 2015/06/08 00:00 [accepted] PHST- 2015/06/23 06:00 [entrez] PHST- 2015/06/23 06:00 [pubmed] PHST- 2015/06/23 06:01 [medline] PHST- 2015/06/13 00:00 [pmc-release] AID - 47 [pii] AID - 10.1186/s12963-015-0047-z [doi] PST - epublish SO - Popul Health Metr. 2015 Jun 13;13:14. doi: 10.1186/s12963-015-0047-z. eCollection 2015.