PMID- 26098356
OWN - NLM
STAT- MEDLINE
DCOM- 20160328
LR  - 20190930
IS  - 1560-2281 (Electronic)
IS  - 1083-3668 (Linking)
VI  - 20
IP  - 6
DP  - 2015 Jun
TI  - High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per 
      second with a 0.9-mm diameter catheter.
PG  - 065006
LID - 10.1117/1.JBO.20.6.065006 [doi]
AB  - Intravascular spectroscopic photoacoustic technology can image atherosclerotic 
      plaque composition with high sensitivity and specificity, which is critical for 
      identifying vulnerable plaques. Here, we designed and engineered a catheter of 
      0.9 mm in diameter for intravascular photoacoustic (IVPA) imaging, smaller than 
      the critical size of 1 mm required for clinical translation. Further, a 
      quasifocusing photoacoustic excitation scheme was developed for the catheter, 
      producing well-detectable IVPA signals from stents and lipids with a laser energy 
      as low as ~30 muJ/pulse. As a result, this design enabled the use of a low-energy, 
      high-repetition rate, ns-pulsed optical parametric oscillator laser for 
      high-speed spectroscopic IVPA imaging at both the 1.2-mum and 1.7-mum spectral 
      bands for lipid detection. Specifically, for each wavelength, a 1-kHz IVPA A-line 
      rate was achieved, ~100-fold faster than previously reported IVPA systems 
      offering a similar wavelength tuning range. Using the system, spectroscopic IVPA 
      imaging of peri-adventitial adipose tissue from a porcine aorta segment was 
      demonstrated. The significantly improved imaging speed, together with the reduced 
      catheter size and multiwavelength spectroscopic imaging ability, suggests that 
      the developed high-speed IVPA technology is of great potential to be further 
      translated for in vivo applications.
FAU - Li, Yan
AU  - Li Y
AD  - Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, 
      Shenzhen Institutes of Advanced Technology, Research Laboratory for Biomedical 
      Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Key 
      Laboratory of Heal.
FAU - Gong, Xiaojing
AU  - Gong X
AD  - Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, 
      Shenzhen Institutes of Advanced Technology, Research Laboratory for Biomedical 
      Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Key 
      Laboratory of Heal.
FAU - Liu, Chengbo
AU  - Liu C
AD  - Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, 
      Shenzhen Institutes of Advanced Technology, Research Laboratory for Biomedical 
      Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Key 
      Laboratory of Heal.
FAU - Lin, Riqiang
AU  - Lin R
AD  - Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, 
      Shenzhen Institutes of Advanced Technology, Research Laboratory for Biomedical 
      Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Key 
      Laboratory of Heal.
FAU - Hau, William
AU  - Hau W
AD  - University of Hong Kong, Institute of Cardiovascular Medicine and Research, Li Ka 
      Shing Faculty of Medicine, Hong Kong, China.
FAU - Bai, Xiaosong
AU  - Bai X
AD  - Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, 
      Shenzhen Institutes of Advanced Technology, Research Laboratory for Biomedical 
      Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Key 
      Laboratory of Heal.
FAU - Song, Liang
AU  - Song L
AD  - Chinese Academy of Sciences, Institute of Biomedical and Health Engineering, 
      Shenzhen Institutes of Advanced Technology, Research Laboratory for Biomedical 
      Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Key 
      Laboratory of Heal.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Opt
JT  - Journal of biomedical optics
JID - 9605853
SB  - IM
MH  - Adipose Tissue/diagnostic imaging
MH  - Animals
MH  - Aorta/diagnostic imaging
MH  - Equipment Design
MH  - Image Processing, Computer-Assisted
MH  - Models, Biological
MH  - Phantoms, Imaging
MH  - Photoacoustic Techniques/*instrumentation/*methods
MH  - Plaque, Atherosclerotic/diagnostic imaging
MH  - Swine
MH  - Ultrasonography, Interventional/*instrumentation/*methods
EDAT- 2015/06/23 06:00
MHDA- 2016/03/29 06:00
CRDT- 2015/06/23 06:00
PHST- 2015/02/25 00:00 [received]
PHST- 2015/05/28 00:00 [accepted]
PHST- 2015/06/23 06:00 [entrez]
PHST- 2015/06/23 06:00 [pubmed]
PHST- 2016/03/29 06:00 [medline]
AID - 2352820 [pii]
AID - 10.1117/1.JBO.20.6.065006 [doi]
PST - ppublish
SO  - J Biomed Opt. 2015 Jun;20(6):065006. doi: 10.1117/1.JBO.20.6.065006.