PMID- 26099424
OWN - NLM
STAT- MEDLINE
DCOM- 20151217
LR  - 20150910
IS  - 1365-3083 (Electronic)
IS  - 0300-9475 (Linking)
VI  - 82
IP  - 4
DP  - 2015 Oct
TI  - Clinical Role of Human Leukocyte Antigen in Health and Disease.
PG  - 283-306
LID - 10.1111/sji.12329 [doi]
AB  - Most of the genes in the major histocompatibility complex (MHC) region express 
      high polymorphism that is fundamental for their function. The most important 
      function of human leukocyte antigen (HLA) molecule is in the induction, 
      regulation of immune responses and the selection of the T cell repertoire. A 
      clinician's attention is normally drawn to a system only when it malfunctions. 
      The HLA system is no exception in this regard, but in contrast to other systems, 
      it also arouses interest when it functions well - too well, in fact. Population 
      studies carried out over the last several decades have identified a long list of 
      human diseases that are significantly more common among individuals that carry 
      particular HLA alleles including inflammatory, autoimmune and malignant 
      disorders. HLA-disease association is the name of this phenomenon, and the 
      mechanism underlying is still a subject of hot debate. Social behaviours are 
      affected by HLA genes and preference for HLA disparate mates may provide 'good 
      genes' for an individual's offspring. Also, certain HLA genes may be associated 
      with shorter life and others with longer lifespan, but the effects depend both on 
      the genetic background and on the environmental conditions. The following is a 
      general overview of the important functional aspects of HLA in health and 
      diseases.
CI  - (c) 2015 The Foundation for the Scandinavian Journal of Immunology.
FAU - Mosaad, Y M
AU  - Mosaad YM
AD  - Clinical Immunology Unit, Clinical Pathology Department & Mansoura Research 
      Center for Cord Stem Cell (MARC_CSC), Mansoura Faculty of Medicine, Mansoura 
      University, Mansoura, Egypt.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Antigen-Presenting Cells/immunology
MH  - Autoimmune Diseases/genetics/immunology
MH  - Dendritic Cells/immunology
MH  - *Genes, MHC Class I
MH  - *Genes, MHC Class II
MH  - HLA Antigens/genetics/*immunology
MH  - Humans
MH  - T-Lymphocytes/immunology
MH  - Transplantation Immunology/genetics/immunology
EDAT- 2015/06/24 06:00
MHDA- 2015/12/19 06:00
CRDT- 2015/06/24 06:00
PHST- 2015/04/23 00:00 [received]
PHST- 2015/06/02 00:00 [revised]
PHST- 2015/06/12 00:00 [accepted]
PHST- 2015/06/24 06:00 [entrez]
PHST- 2015/06/24 06:00 [pubmed]
PHST- 2015/12/19 06:00 [medline]
AID - 10.1111/sji.12329 [doi]
PST - ppublish
SO  - Scand J Immunol. 2015 Oct;82(4):283-306. doi: 10.1111/sji.12329.