PMID- 26099630
OWN - NLM
STAT- MEDLINE
DCOM- 20160315
LR  - 20221207
IS  - 1471-2369 (Electronic)
IS  - 1471-2369 (Linking)
VI  - 16
DP  - 2015 Jun 18
TI  - Association between 24-hour blood pressure variability and chronic kidney 
      disease: a cross-sectional analysis of African Americans participating in the 
      Jackson heart study.
PG  - 84
LID - 10.1186/s12882-015-0085-6 [doi]
LID - 84
AB  - BACKGROUND: Studies suggest 24-h blood pressure (BP) variability has prognostic 
      value for cardiovascular disease. Several factors associated with high 24-h BP 
      variability are also common among individuals with chronic kidney disease (CKD). 
      We hypothesized 24-h BP variability would be higher for individuals with versus 
      without CKD. METHODS: We analyzed 1,022 Jackson Heart Study participants who 
      underwent ambulatory blood pressure monitoring (ABPM). Twenty-four hour BP 
      variability was defined by two metrics: day-night standard deviation (SDdn) and 
      average real variability (ARV). CKD was defined as ACR >/= 30 mg/g or eGFR <60 
      mL/min/1.73 m(2). RESULTS: The mean SDdn of systolic BP (SBP) was 10.2 +/- 0.2 and 
      9.1 +/- 0.1 mmHg and the mean ARV of SBP was 9.2 +/- 0.2 and 8.6 +/- 0.1 mmHg for those 
      with and without CKD, respectively (each p </= 0.001). After adjustment for age and 
      sex, SDdn and ARV were 0.98 mmHg (95 % CI 0.59, 1.38) and 0.52 mmHg (95 % CI 
      0.18, 0.86), respectively, higher among participants with versus without CKD. 
      These differences were not statistically significant after further multivariable 
      adjustment including 24-h mean SBP. Older age, and higher total cholesterol and 
      24-h mean SBP were associated with higher SDdn and ARV of SBP among participants 
      with CKD. Mean SDdn and ARV of diastolic BP (DBP) were higher for participants 
      with versus without CKD but these associations were not present after 
      multivariable adjustment. CONCLUSION: Data from the current study suggest that 
      CKD is associated with higher 24-h BP variability, but the association is 
      primarily explained by higher mean BP among those with CKD.
FAU - Tanner, Rikki M
AU  - Tanner RM
AD  - Department of Epidemiology, University of Alabama at Birmingham, 1665 University 
      Boulevard, Suite 230 J, Birmingham, AL, 35294, USA. rmdeitz@uab.edu.
FAU - Shimbo, Daichi
AU  - Shimbo D
AD  - Columbia University Medical Center, New York, NY, USA. ds2231@cumc.columbia.edu.
FAU - Dreisbach, Albert W
AU  - Dreisbach AW
AD  - Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 
      USA. adreisbach@umc.edu.
FAU - Carson, April P
AU  - Carson AP
AD  - Department of Epidemiology, University of Alabama at Birmingham, 1665 University 
      Boulevard, Suite 230 J, Birmingham, AL, 35294, USA. apcarson@uab.edu.
FAU - Fox, Ervin R
AU  - Fox ER
AD  - Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 
      USA. efox@umc.edu.
FAU - Muntner, Paul
AU  - Muntner P
AD  - Department of Epidemiology, University of Alabama at Birmingham, 1665 University 
      Boulevard, Suite 230 J, Birmingham, AL, 35294, USA. pmuntner@uab.edu.
LA  - eng
GR  - HHSN268201300049C/PHS HHS/United States
GR  - HHSN268201300048C/PHS HHS/United States
GR  - P01 HL047540/HL/NHLBI NIH HHS/United States
GR  - HHSN268201300047C/PHS HHS/United States
GR  - HHSN268201300048C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201300049C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201300050C/PHS HHS/United States
GR  - HHSN268201300046C/PHS HHS/United States
GR  - HHSN268201300047C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201300050C/HL/NHLBI NIH HHS/United States
GR  - P01-HL047540/HL/NHLBI NIH HHS/United States
GR  - R01 HL117323/HL/NHLBI NIH HHS/United States
GR  - HHSN268201300046C/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150618
PL  - England
TA  - BMC Nephrol
JT  - BMC nephrology
JID - 100967793
RN  - 0 (Cholesterol, HDL)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - *Black or African American
MH  - Age Factors
MH  - Blood Pressure/*physiology
MH  - Blood Pressure Monitoring, Ambulatory
MH  - Cardiovascular Diseases/epidemiology/physiopathology
MH  - Case-Control Studies
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Cross-Sectional Studies
MH  - Diastole
MH  - Female
MH  - Humans
MH  - Hypercholesterolemia/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Renal Insufficiency, Chronic/epidemiology/*physiopathology
MH  - Risk Factors
MH  - Systole
PMC - PMC4477603
EDAT- 2015/06/24 06:00
MHDA- 2016/03/16 06:00
PMCR- 2015/06/18
CRDT- 2015/06/24 06:00
PHST- 2015/02/19 00:00 [received]
PHST- 2015/06/04 00:00 [accepted]
PHST- 2015/06/24 06:00 [entrez]
PHST- 2015/06/24 06:00 [pubmed]
PHST- 2016/03/16 06:00 [medline]
PHST- 2015/06/18 00:00 [pmc-release]
AID - 10.1186/s12882-015-0085-6 [pii]
AID - 85 [pii]
AID - 10.1186/s12882-015-0085-6 [doi]
PST - epublish
SO  - BMC Nephrol. 2015 Jun 18;16:84. doi: 10.1186/s12882-015-0085-6.