PMID- 2610096
OWN - NLM
STAT- MEDLINE
DCOM- 19900209
LR  - 20190622
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 247B
DP  - 1989
TI  - Studies on the mechanism of the sedational state; "tranquilization" evoked by 
      bradykinin or kallikrein in rats.
PG  - 595-600
AB  - The mechanism of the sedative state "tranquilization" evoked by bradykinin(BK) or 
      kallikrein(Kal), was studied. The drugs were injected 
      intracerebroventricularly(icv) into the lateral ventricle, according to Yaksh's 
      procedure. The behavior of a rat was estimated comparatively by the spontaneous 
      movement. Two groups of animals were examined; one group was pretreated with 
      prostaglandin (PG)-synthesis inhibitors, and the other group was not pretreated. 
      The tranquilization was observed at the period of 12 to 16 min after BK or Kal 
      injection. Almost of the PG-synthesis inhibitors reduced the tranquilization. On 
      the contrary, eugenol or guaiacol, elongated the tranquilization. The levels of 
      monoamines and PGs in the rat brain at the tranquilization, 15 min after BK 
      injection detected with HPLC (high performance liquid chromatography). The levels 
      of almost monoamines in the rat brain were decreased, however, PGE2 was increased 
      considerably. Those results suggest that PGs is greatly involved in 
      tranquilization evoked by BK or Kal.
FAU - Yazaki, K
AU  - Yazaki K
AD  - Department of Pharmacology, Tokyo Dental College, Chiba, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Prostaglandins)
RN  - 0 (Prostaglandins E)
RN  - 0 (Tranquilizing Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - EC 3.4.21.- (Kallikreins)
RN  - H0C805XYDE (Quinacrine)
RN  - S8TIM42R2W (Bradykinin)
RN  - VTD58H1Z2X (Dopamine)
RN  - XXE1CET956 (Indomethacin)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Animals
MH  - Bradykinin/administration & dosage/*pharmacology
MH  - Brain/drug effects/metabolism
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Dopamine/metabolism
MH  - Epinephrine/metabolism
MH  - Indomethacin/pharmacology
MH  - Injections, Intraventricular
MH  - Kallikreins/administration & dosage/*pharmacology
MH  - Male
MH  - Motor Activity/*drug effects
MH  - Prostaglandins/metabolism
MH  - Prostaglandins E/administration & dosage/pharmacology
MH  - Quinacrine/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
MH  - Serotonin/metabolism
MH  - *Tranquilizing Agents
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1007/978-1-4615-9546-5_97 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 1989;247B:595-600. doi: 10.1007/978-1-4615-9546-5_97.