PMID- 26101023
OWN - NLM
STAT- MEDLINE
DCOM- 20170209
LR  - 20170529
IS  - 1897-4279 (Electronic)
IS  - 0022-9032 (Linking)
VI  - 74
IP  - 1
DP  - 2016
TI  - Heart failure is the strongest predictor of acute kidney injury in patients 
      undergoing primary percutaneous coronary intervention for ST-elevation myocardial 
      infarction.
PG  - 18-24
LID - 10.5603/KP.a2015.0115 [doi]
AB  - BACKGROUND: ST elevation myocardial infarction (STEMI) patients treated by 
      primary percutaneous coronary intervention (PCI) are at higher risk of acute 
      kidney injury (AKI) than patients undergoing PCI in stable clinical conditions. 
      This fact suggests that mechanisms other than contrast nephrotoxicity are 
      involved. AIM: To evaluate the incidence, risk factors, and consequences of AKI 
      in patients undergoing primary PCI for STEMI in current daily practice. METHODS: 
      Analysis of all consecutive patients who underwent primary PCI over a one-year 
      period. AKI was defined as an increase in serum creatinine >/= 50% or 26.5 mumol/L 
      (AKIN criteria) from the baseline within 48 h. RESULTS: A total of 202 patients 
      were included. AKI occurred in 25 (12.4%) subjects. Baseline characteristics and 
      in-hospital complications of the patients with and without AKI did not differ 
      significantly except for age (69 +/- 13 vs. 62 +/- 12; p = 0.003), female gender 
      (48.0% vs. 26.6%; p = 0.035), hypertension (88.0% vs. 62.7%; p = 0.013), left 
      ventricular ejection fraction (40% +/- 12% vs. 49% +/- 14%; p = 0.002), cardiogenic 
      shock (44.0% vs. 5.1%; p < 0.0001), use of intravenous diuretics (76.0% vs. 
      26.0%; p < 0.0001), ventricular arrhythmias (24.0% vs. 3.4%; p = 0.001), and 
      in-hospital mortality (24.0% vs. 3.4%; p = 0.001). In multivariate analysis heart 
      failure remained the only independent correlate of AKI. CONCLUSIONS: AKI was an 
      frequent and serious complication of STEMI in patients treated by primary PCI. 
      Heart failure was the strongest predictor of AKI. Other risk factors including 
      contrast medium volume, baseline renal function, diabetes, and age failed to 
      predict AKI.
FAU - Matejka, Jan
AU  - Matejka J
AD  - Cardiology Centre AGEL, Pardubice, Czech Republic Department of Cardiology, 
      Regional Hospital Pardubice, Czech Republic Faculty of Health Studies, University 
      of Pardubice, Czech Republic. matejcata@gmail.com.
FAU - Varvarovsky, Ivo
AU  - Varvarovsky I
FAU - Rozsival, Vladimir
AU  - Rozsival V
FAU - Herman, Ales
AU  - Herman A
FAU - Blaha, Karel
AU  - Blaha K
FAU - Vecera, Jan
AU  - Vecera J
FAU - Lazarak, Tomas
AU  - Lazarak T
FAU - Novotny, Vojtech
AU  - Novotny V
FAU - Muzakova, Vladimira
AU  - Muzakova V
FAU - Vojtisek, Petr
AU  - Vojtisek P
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Kardiol Pol
JT  - Kardiologia polska
JID - 0376352
RN  - 0 (Contrast Media)
SB  - IM
MH  - Acute Kidney Injury/epidemiology/*etiology
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Contrast Media/adverse effects
MH  - Female
MH  - Heart Failure
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention/*adverse effects
MH  - Retrospective Studies
MH  - Risk Factors
MH  - ST Elevation Myocardial Infarction/*surgery
EDAT- 2015/06/24 06:00
MHDA- 2017/02/10 06:00
CRDT- 2015/06/24 06:00
PHST- 2014/11/07 00:00 [received]
PHST- 2015/05/07 00:00 [accepted]
PHST- 2015/03/22 00:00 [revised]
PHST- 2015/06/24 06:00 [entrez]
PHST- 2015/06/24 06:00 [pubmed]
PHST- 2017/02/10 06:00 [medline]
AID - VM/OJS/KP/9249 [pii]
AID - 10.5603/KP.a2015.0115 [doi]
PST - ppublish
SO  - Kardiol Pol. 2016;74(1):18-24. doi: 10.5603/KP.a2015.0115.