PMID- 26102094
OWN - NLM
STAT- MEDLINE
DCOM- 20160609
LR  - 20211203
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 18
IP  - 9
DP  - 2015 Sep
TI  - Solanum tuberosum L. cv Jayoung Epidermis Extract Inhibits Mite Antigen-Induced 
      Atopic Dermatitis in NC/Nga Mice by Regulating the Th1/Th2 Balance and Expression 
      of Filaggrin.
PG  - 1013-21
LID - 10.1089/jmf.2014.3338 [doi]
AB  - Solanum tuberosum L. cv Jayoung (JY) is a potato with dark purple flesh and 
      contains substantial amounts of polyphenols. In this study, we evaluated the 
      therapeutic effects of S. tuberosum L. cv JY in a mouse model of Dermatophagoides 
      farinae body (Dfb)-induced atopic dermatitis (AD). The ethanol extract of the 
      peel of JY (EPJ) ameliorated Dfb-induced dermatitis severity, serum levels of 
      immunoglobulin E (IgE) and thymus and activation-regulated chemokine. 
      Histological analysis of the skin also revealed that EPJ treatment significantly 
      decreased mast cell infiltration. The suppression of dermatitis by EPJ treatment 
      was accompanied by a decrease in the skin levels of type 2 helper T-cell 
      cytokines such as interleukin (IL)-4, IL-5, and IL-13. The induction of thymic 
      stromal lymphopoietin, which leads to a systemic Th2 response, was also decreased 
      in the skin by EPJ. Nuclear translocation of nuclear factor-kappaB p65 was decreased 
      by EPJ in Dfb-induced NC/Nga mice. The protein expression of filaggrin in the 
      AD-like skin lesions was restored by EPJ treatment. These results suggested that 
      EPJ may be a potential therapeutic tool for the treatment of AD.
FAU - Yang, Gabsik
AU  - Yang G
AD  - 1 Department of Oriental Pharmacology, College of Oriental Medicine, Sangji 
      University , Gangwon, Korea.
FAU - Cheon, Se-Yun
AU  - Cheon SY
AD  - 1 Department of Oriental Pharmacology, College of Oriental Medicine, Sangji 
      University , Gangwon, Korea.
FAU - Chung, Kyung-Sook
AU  - Chung KS
AD  - 1 Department of Oriental Pharmacology, College of Oriental Medicine, Sangji 
      University , Gangwon, Korea.
FAU - Lee, Sung-Jin
AU  - Lee SJ
AD  - 2 Department of Oriental Ophthalmology, Otolaryngology, and Dermatology Medicine, 
      College of Oriental Medicine, Sangji University , Gangwon, Korea.
FAU - Hong, Chul-Hee
AU  - Hong CH
AD  - 2 Department of Oriental Ophthalmology, Otolaryngology, and Dermatology Medicine, 
      College of Oriental Medicine, Sangji University , Gangwon, Korea.
FAU - Lee, Kyung-Tae
AU  - Lee KT
AD  - 3 Department of Pharmaceutical Biochemistry, Kyung Hee University , Seoul, Korea.
AD  - 4 Department of Life and Nanopharmaceutical Science, Kyung Hee University , 
      Seoul, Korea.
FAU - Jang, Dae-Sik
AU  - Jang DS
AD  - 4 Department of Life and Nanopharmaceutical Science, Kyung Hee University , 
      Seoul, Korea.
FAU - Jeong, Jin-Cheol
AU  - Jeong JC
AD  - 5 Highland Agriculture Research Center, National Institute of Crop Science , 
      Rural Development Administration, Gangwon, Korea.
FAU - Kwon, Oh-Keun
AU  - Kwon OK
AD  - 5 Highland Agriculture Research Center, National Institute of Crop Science , 
      Rural Development Administration, Gangwon, Korea.
FAU - Nam, Jung-Hwan
AU  - Nam JH
AD  - 5 Highland Agriculture Research Center, National Institute of Crop Science , 
      Rural Development Administration, Gangwon, Korea.
FAU - An, Hyo-Jin
AU  - An HJ
AD  - 1 Department of Oriental Pharmacology, College of Oriental Medicine, Sangji 
      University , Gangwon, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150623
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Antigens)
RN  - 0 (Cytokines)
RN  - 0 (Filaggrin Proteins)
RN  - 0 (Intermediate Filament Proteins)
RN  - 0 (Plant Extracts)
RN  - 0 (Polyphenols)
SB  - IM
MH  - Animals
MH  - Antigens
MH  - Cytokines/blood
MH  - Dermatitis, Atopic/*drug therapy/etiology/immunology/metabolism
MH  - Filaggrin Proteins
MH  - Intermediate Filament Proteins/metabolism
MH  - Male
MH  - Mice
MH  - *Mites
MH  - *Phytotherapy
MH  - Plant Epidermis
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - Polyphenols/pharmacology/therapeutic use
MH  - Skin/*drug effects/metabolism/pathology
MH  - Solanum tuberosum/*chemistry
MH  - T-Lymphocytes, Helper-Inducer/metabolism
MH  - Th1 Cells/metabolism
MH  - Th1-Th2 Balance/*drug effects
MH  - Th2 Cells/metabolism
OTO - NOTNLM
OT  - IgE
OT  - NF-kappaB
OT  - Solanum tuberosum L. cv Jayoung
OT  - Th2
OT  - atopic dermatitis
EDAT- 2015/06/24 06:00
MHDA- 2016/06/10 06:00
CRDT- 2015/06/24 06:00
PHST- 2015/06/24 06:00 [entrez]
PHST- 2015/06/24 06:00 [pubmed]
PHST- 2016/06/10 06:00 [medline]
AID - 10.1089/jmf.2014.3338 [doi]
PST - ppublish
SO  - J Med Food. 2015 Sep;18(9):1013-21. doi: 10.1089/jmf.2014.3338. Epub 2015 Jun 23.