PMID- 26103118
OWN - NLM
STAT- MEDLINE
DCOM- 20160310
LR  - 20150624
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Linking)
VI  - 26
IP  - 11
DP  - 2015 Aug 5
TI  - Increased serum levels of brain-derived neurotrophic factor in autism spectrum 
      disorder.
PG  - 638-41
LID - 10.1097/WNR.0000000000000404 [doi]
AB  - The aim of this study was to investigate the potential role of brain-derived 
      neurotrophic factor (BDNF) in children with autism spectrum disorders (ASD) by 
      measuring serum circulating levels of BDNF as well as calcium and comparing them 
      with age-matched and sex-matched normal controls. The study included 75 
      drug-naive ASD children and 75 age-sex-matched healthy children. The 
      concentration of serum BDNF was determined using the enzyme-linked immunosorbent 
      assay method at baseline. Clinical information was collected. The severity of ASD 
      was assessed at admission using the Childhood Autism Rating Scale total score. 
      The results indicated that the mean serum BDNF levels were significantly 
      (P<0.0001) higher in children with ASD compared with the control cases 
      (17.59+/-5.55 vs. 11.21+/-2.79 ng/ml; t=8.902). On the basis of the receiver 
      operating characteristic curve, the optimal cutoff value of serum BDNF levels as 
      an indicator for auxiliary diagnosis of autism was projected to be 12.65 ng/ml, 
      which yielded a sensitivity of 80.8% and a specificity of 70.2%; the area under 
      the curve was 0.840 [95% confidence interval (CI), 0.777-0.904]. In univariate 
      logistic regression analysis, with an unadjusted odds ratio of 9.42 (95% CI, 
      4.33-25.95; P<0.0001), BDNF of 12.65 ng/ml or more had an association with a 
      diagnosis of ASD. After adjusting for possible covariates, BDNF of 12.65 ng/ml or 
      more is still an independent indicator of ASD, with an adjusted odds ratio of 
      7.33 (95% CI, 2.98-16.55; P<0.0001). Serum BDNF levels may be associated 
      independently with the severity of ASD, and higher BDNF levels could be 
      considered an independent diagnostic marker of ASD.
FAU - Wang, Min
AU  - Wang M
AD  - aDepartment of Neurology, Yantaishan Hospital Departments of bNeurosurgery 
      cOncology, Yuhuangding Hospital, Yantai, People's Republic of China.
FAU - Chen, Hongguang
AU  - Chen H
FAU - Yu, Tianxia
AU  - Yu T
FAU - Cui, Guangqiang
AU  - Cui G
FAU - Jiao, Aihong
AU  - Jiao A
FAU - Liang, Hui
AU  - Liang H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (brain-derived growth factor)
SB  - IM
MH  - Autism Spectrum Disorder/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Chi-Square Distribution
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
EDAT- 2015/06/24 06:00
MHDA- 2016/03/11 06:00
CRDT- 2015/06/24 06:00
PHST- 2015/06/24 06:00 [entrez]
PHST- 2015/06/24 06:00 [pubmed]
PHST- 2016/03/11 06:00 [medline]
AID - 00001756-201508010-00007 [pii]
AID - 10.1097/WNR.0000000000000404 [doi]
PST - ppublish
SO  - Neuroreport. 2015 Aug 5;26(11):638-41. doi: 10.1097/WNR.0000000000000404.