PMID- 26103138
OWN - NLM
STAT- MEDLINE
DCOM- 20160526
LR  - 20191210
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 123
DP  - 2015 Sep
TI  - Kisspeptin-13 enhances memory and mitigates memory impairment induced by Abeta1-42 
      in mice novel object and object location recognition tasks.
PG  - 187-95
LID - S1074-7427(15)00112-4 [pii]
LID - 10.1016/j.nlm.2015.05.010 [doi]
AB  - Kisspeptin (KP), the endogenous ligand of GPR54, is a recently discovered 
      neuropeptide shown to be involved in regulating reproductive system, 
      anxiety-related behavior, locomotion, food intake, and suppression of metastasis 
      across a range of cancers. KP is transcribed within the hippocampus, and GPR54 
      has been found in the amygdala and hippocampus, suggesting that KP might be 
      involved in mediating learning and memory. However, the role of KP in cognition 
      was largely unclear. Here, we investigated the role of KP-13, one of the 
      endogenous active isoforms, in memory processes, and determined whether KP-13 
      could mitigate memory impairment induced by Abeta1-42 in mice, using novel object 
      recognition (NOR) and object location recognition (OLR) tasks. 
      Intracerebroventricular (i.c.v.) infusion of KP-13 (2mug) immediately after 
      training not only facilitated memory formation, but also prolonged memory 
      retention in both tasks. The memory-improving effects of KP-13 could be blocked 
      by the GPR54 receptor antagonist, kisspeptin-234 (234), and GnRH receptors 
      antagonist, Cetrorelix, suggesting pharmacological specificity. Then the 
      memory-enhancing effects were also presented after infusion of KP-13 into the 
      hippocampus. Moreover, we found that i.c.v. injection of KP-13 was able to 
      reverse the memory impairment induced by Abeta1-42, which was inhibited by 234. To 
      sum up, the results of our work indicate that KP-13 could facilitate memory 
      formation and prolong memory retention through activation of the GPR54 and GnRH 
      receptors, and suppress memory-impairing effect of Abeta1-42 through activation of 
      the GPR54, suggesting that KP-13 may be a potential drug for enhancing memory and 
      treating Alzheimer's disease.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Jiang, J H
AU  - Jiang JH
AD  - Institute of Biochemistry and Molecular Biology, School of Life Sciences, Key 
      Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou 
      University, Lanzhou 730000, China.
FAU - He, Z
AU  - He Z
AD  - Institute of Biochemistry and Molecular Biology, School of Life Sciences, Key 
      Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou 
      University, Lanzhou 730000, China.
FAU - Peng, Y L
AU  - Peng YL
AD  - Institute of Biochemistry and Molecular Biology, School of Life Sciences, Key 
      Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou 
      University, Lanzhou 730000, China.
FAU - Jin, W D
AU  - Jin WD
AD  - Institute of Biochemistry and Molecular Biology, School of Life Sciences, Key 
      Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou 
      University, Lanzhou 730000, China.
FAU - Wang, Z
AU  - Wang Z
AD  - Institute of Biochemistry and Molecular Biology, School of Life Sciences, Key 
      Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou 
      University, Lanzhou 730000, China.
FAU - Han, R W
AU  - Han RW
AD  - Institute of Translational Medicine, Nanchang University, Nanchang 330088, China.
FAU - Chang, M
AU  - Chang M
AD  - Institute of Biochemistry and Molecular Biology, School of Life Sciences, Key 
      Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou 
      University, Lanzhou 730000, China. Electronic address: changmin@lzu.edu.cn.
FAU - Wang, R
AU  - Wang R
AD  - Institute of Biochemistry and Molecular Biology, School of Life Sciences, Key 
      Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou 
      University, Lanzhou 730000, China. Electronic address: wangrui@lzu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150620
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Hormone Antagonists)
RN  - 0 (Kiss1r protein, mouse)
RN  - 0 (Kisspeptins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Receptors, Kisspeptin-1)
RN  - 0 (Receptors, LHRH)
RN  - 0 (amyloid beta-protein (1-42))
RN  - 0 (kisspeptin-13, mouse)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - OON1HFZ4BA (cetrorelix)
SB  - IM
MH  - Amyloid beta-Peptides/*pharmacology
MH  - Animals
MH  - Gonadotropin-Releasing Hormone/analogs & derivatives/pharmacology
MH  - Hippocampus/drug effects/*metabolism
MH  - Hormone Antagonists/pharmacology
MH  - Infusions, Intraventricular
MH  - Kisspeptins/administration & dosage/*pharmacology
MH  - Male
MH  - Memory Disorders/chemically induced/*drug therapy
MH  - Mice
MH  - Peptide Fragments/*pharmacology
MH  - Receptors, G-Protein-Coupled/antagonists & inhibitors/*metabolism
MH  - Receptors, Kisspeptin-1
MH  - Receptors, LHRH/antagonists & inhibitors/*metabolism
MH  - Recognition, Psychology/drug effects
MH  - Retention, Psychology/drug effects
MH  - Spatial Memory/*drug effects
OTO - NOTNLM
OT  - Abeta(1-42)
OT  - GPR54
OT  - GnRH
OT  - Hippocampus
OT  - Kisspeptin-13
OT  - Recognition memory
EDAT- 2015/06/24 06:00
MHDA- 2016/05/27 06:00
CRDT- 2015/06/24 06:00
PHST- 2015/02/01 00:00 [received]
PHST- 2015/04/16 00:00 [revised]
PHST- 2015/05/26 00:00 [accepted]
PHST- 2015/06/24 06:00 [entrez]
PHST- 2015/06/24 06:00 [pubmed]
PHST- 2016/05/27 06:00 [medline]
AID - S1074-7427(15)00112-4 [pii]
AID - 10.1016/j.nlm.2015.05.010 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2015 Sep;123:187-95. doi: 10.1016/j.nlm.2015.05.010. Epub 
      2015 Jun 20.