PMID- 26104932
OWN - NLM
STAT- MEDLINE
DCOM- 20150903
LR  - 20220331
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 92
IP  - 4
DP  - 2015 Jul 15
TI  - Quality of Intensity Modulated Radiation Therapy Treatment Plans Using a (6)(0)Co 
      Magnetic Resonance Image Guidance Radiation Therapy System.
PG  - 771-8
LID - S0360-3016(15)00300-4 [pii]
LID - 10.1016/j.ijrobp.2015.02.057 [doi]
AB  - PURPOSE: This work describes a commercial treatment planning system, its 
      technical features, and its capabilities for creating (60)Co intensity modulated 
      radiation therapy (IMRT) treatment plans for a magnetic resonance image guidance 
      radiation therapy (MR-IGRT) system. METHODS AND MATERIALS: The ViewRay treatment 
      planning system (Oakwood Village, OH) was used to create (60)Co IMRT treatment 
      plans for 33 cancer patients with disease in the abdominal, pelvic, thorax, and 
      head and neck regions using physician-specified patient-specific target coverage 
      and organ at risk (OAR) objectives. Backup plans using a third-party linear 
      accelerator (linac)-based planning system were also created. Plans were evaluated 
      by attending physicians and approved for treatment. The (60)Co and linac plans 
      were compared by evaluating conformity numbers (CN) with 100% and 95% of 
      prescription reference doses and heterogeneity indices (HI) for planning target 
      volumes (PTVs) and maximum, mean, and dose-volume histogram (DVH) values for 
      OARs. RESULTS: All (60)Co IMRT plans achieved PTV coverage and OAR sparing that 
      were similar to linac plans. PTV conformity for (60)Co was within <1% and 3% of 
      linac plans for 100% and 95% prescription reference isodoses, respectively, and 
      heterogeneity was on average 4% greater. Comparisons of OAR mean dose showed 
      generally better sparing with linac plans in the low-dose range <20 Gy, but 
      comparable sparing for organs with mean doses >20 Gy. The mean doses for all 
      (60)Co plan OARs were within clinical tolerances. CONCLUSIONS: A commercial 
      (60)Co MR-IGRT device can produce highly conformal IMRT treatment plans similar 
      in quality to linac IMRT for a variety of disease sites. Additional work is in 
      progress to evaluate the clinical benefit of other novel features of this MR-IGRT 
      system.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Wooten, H Omar
AU  - Wooten HO
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri. Electronic address: hwooten@radonc.wustl.edu.
FAU - Green, Olga
AU  - Green O
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Yang, Min
AU  - Yang M
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - DeWees, Todd
AU  - DeWees T
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Kashani, Rojano
AU  - Kashani R
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Olsen, Jeff
AU  - Olsen J
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Michalski, Jeff
AU  - Michalski J
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Yang, Deshan
AU  - Yang D
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Tanderup, Kari
AU  - Tanderup K
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Hu, Yanle
AU  - Hu Y
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Li, H Harold
AU  - Li HH
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
FAU - Mutic, Sasa
AU  - Mutic S
AD  - Department of Radiation Oncology, Washington University School of Medicine, St. 
      Louis, Missouri.
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20150317
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
RN  - 0 (Cobalt Radioisotopes)
SB  - IM
MH  - Abdominal Neoplasms/radiotherapy
MH  - Algorithms
MH  - Cobalt Radioisotopes/*therapeutic use
MH  - Head and Neck Neoplasms/radiotherapy
MH  - Humans
MH  - Magnetic Resonance Imaging/*instrumentation/methods/standards
MH  - Monte Carlo Method
MH  - Neoplasms/*radiotherapy
MH  - Organs at Risk/radiation effects
MH  - Particle Accelerators
MH  - Patient Positioning/methods
MH  - Pelvic Neoplasms/radiotherapy
MH  - Radiation Injuries/prevention & control
MH  - Radiotherapy Dosage
MH  - Radiotherapy, Image-Guided/*instrumentation/methods/standards
MH  - Radiotherapy, Intensity-Modulated/*instrumentation/methods/standards
MH  - Thoracic Neoplasms/radiotherapy
EDAT- 2015/06/25 06:00
MHDA- 2015/09/04 06:00
CRDT- 2015/06/25 06:00
PHST- 2014/10/12 00:00 [received]
PHST- 2015/01/19 00:00 [revised]
PHST- 2015/02/13 00:00 [accepted]
PHST- 2015/06/25 06:00 [entrez]
PHST- 2015/06/25 06:00 [pubmed]
PHST- 2015/09/04 06:00 [medline]
AID - S0360-3016(15)00300-4 [pii]
AID - 10.1016/j.ijrobp.2015.02.057 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2015 Jul 15;92(4):771-8. doi: 
      10.1016/j.ijrobp.2015.02.057. Epub 2015 Mar 17.