PMID- 26106001
OWN - NLM
STAT- MEDLINE
DCOM- 20160324
LR  - 20190604
IS  - 1880-9952 (Electronic)
IS  - 1346-4280 (Linking)
VI  - 55
IP  - 1
DP  - 2015
TI  - Mutation Analysis for TP53 in Chronic-Type Adult T-Cell Leukemia/Lymphoma.
PG  - 13-6
LID - 10.3960/jslrt.55.13 [doi]
AB  - Adult T-cell leukemia/lymphoma (ATLL) is a T-cell neoplasm caused by human T-cell 
      leukemia virus type I (HTLV-I). ATLL is classified into four clinical subtypes 
      based on the clinical manifestation: acute, lymphoma, chronic and smoldering. 
      Approximately half of chronic type ATLL cases progressed to the acute type. We 
      previously demonstrated that genomic alterations related to the cell cycle 
      de-regulation such as CDKN2A and immune escape such as CD58 alteration can serve 
      as predictive biomarkers for acute transformation of the chronic type. Although 
      alteration of TP53, which is known to be a major regulator of cell cycle, has 
      been identified in several types of cancers including acute type ATLL, no copy 
      number alteration of TP53 was found in the chronic type by array comparative 
      genomic hybridization. In the present study, mutation of TP53 was further 
      analyzed by sequencing for these cases as well as HTLV-I carriers with 
      oligo-clonality. However, no TP53 mutation was identified. These results 
      suggested that TP53 mutation plays a role for the later stage of ATLL 
      development.
FAU - Yoshida, Noriaki
AU  - Yoshida N
AD  - Department of Pathology, Kurume University School of Medicine.
FAU - Imaizumi, Yoshitaka
AU  - Imaizumi Y
FAU - Utsunomiya, Atae
AU  - Utsunomiya A
FAU - Miyoshi, Hiroaki
AU  - Miyoshi H
FAU - Arakawa, Fumiko
AU  - Arakawa F
FAU - Tsukasaki, Kunihiro
AU  - Tsukasaki K
FAU - Ohshima, Koichi
AU  - Ohshima K
FAU - Seto, Masao
AU  - Seto M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Clin Exp Hematop
JT  - Journal of clinical and experimental hematopathology : JCEH
JID - 101141257
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Cell Cycle/genetics
MH  - Chronic Disease
MH  - Cyclin-Dependent Kinase Inhibitor p16/genetics
MH  - DNA Mutational Analysis
MH  - Disease Progression
MH  - Human T-lymphotropic virus 1
MH  - Humans
MH  - Leukemia-Lymphoma, Adult T-Cell/diagnosis/*genetics/virology
MH  - *Mutation
MH  - Polymorphism, Single Nucleotide
MH  - Tumor Suppressor Protein p53/*genetics
EDAT- 2015/06/25 06:00
MHDA- 2016/03/25 06:00
CRDT- 2015/06/25 06:00
PHST- 2015/06/25 06:00 [entrez]
PHST- 2015/06/25 06:00 [pubmed]
PHST- 2016/03/25 06:00 [medline]
AID - 10.3960/jslrt.55.13 [doi]
PST - ppublish
SO  - J Clin Exp Hematop. 2015;55(1):13-6. doi: 10.3960/jslrt.55.13.