PMID- 26106296
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150624
LR  - 20200930
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 9
DP  - 2015
TI  - Facial stimulation induces long-term depression at cerebellar molecular layer 
      interneuron-Purkinje cell synapses in vivo in mice.
PG  - 214
LID - 10.3389/fncel.2015.00214 [doi]
LID - 214
AB  - Cerebellar long-term synaptic plasticity has been proposed to provide a cellular 
      mechanism for motor learning. Numerous studies have demonstrated the induction 
      and mechanisms of synaptic plasticity at parallel fiber-Purkinje cell (PF-PC), 
      parallel fiber-molecular layer interneurons (PF-MLI) and mossy fiber-granule cell 
      (MF-GC) synapses, but no study has investigated sensory stimulation-evoked 
      synaptic plasticity at MLI-PC synapses in the cerebellar cortex of living 
      animals. We studied the expression and mechanism of MLI-PC GABAergic synaptic 
      plasticity induced by a train of facial stimulation in urethane-anesthetized mice 
      by cell-attached recordings and pharmacological methods. We found that 1 Hz, but 
      not a 2 Hz or 4 Hz, facial stimulation induced a long-term depression (LTD) of 
      GABAergic transmission at MLI-PC synapses, which was accompanied with a decrease 
      in the stimulation-evoked pause of spike firing in PCs, but did not induce a 
      significant change in the properties of the sensory-evoked spike events of MLIs. 
      The MLI-PC GABAergic LTD could be prevented by blocking cannabinoid type 1 (CB1) 
      receptors, and could be pharmacologically induced by a CB1 receptor agonist. 
      Additionally, 1 Hz facial stimulation delivered in the presence of a metabotropic 
      glutamate receptor 1 (mGluR1) antagonist, JNJ16259685, still induced the MLI-PC 
      GABAergic LTD, whereas blocking N-methyl-D-aspartate (NMDA) receptors during 1 Hz 
      facial stimulation abolished the expression of MLI-PC GABAergic LTD. These 
      results indicate that sensory stimulation can induce an endocannabinoid 
      (eCB)-dependent LTD of GABAergic transmission at MLI-PC synapses via activation 
      of NMDA receptors in cerebellar cortical Crus II in vivo in mice. Our results 
      suggest that the sensory stimulation-evoked MLI-PC GABAergic synaptic plasticity 
      may play a critical role in motor learning in animals.
FAU - Bing, Yan-Hua
AU  - Bing YH
AD  - Cellular Function Research Center, Yanbian University Yanji, Jilin Province, 
      China ; Department of Physiology and Pathophysiology, College of Medicine, 
      Yanbian University Yanji, Jilin Province, China.
FAU - Wu, Mao-Cheng
AU  - Wu MC
AD  - Cellular Function Research Center, Yanbian University Yanji, Jilin Province, 
      China ; Department of Osteology, Affiliated Hospital of Yanbian University Yanji, 
      Jilin Province, China.
FAU - Chu, Chun-Ping
AU  - Chu CP
AD  - Cellular Function Research Center, Yanbian University Yanji, Jilin Province, 
      China.
FAU - Qiu, De-Lai
AU  - Qiu DL
AD  - Cellular Function Research Center, Yanbian University Yanji, Jilin Province, 
      China ; Department of Physiology and Pathophysiology, College of Medicine, 
      Yanbian University Yanji, Jilin Province, China.
LA  - eng
PT  - Journal Article
DEP - 20150609
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC4460530
OTO - NOTNLM
OT  - NMDA receptor
OT  - cerebellar Purkinje cell
OT  - endocannabinoids receptor
OT  - in vivo cell-attached recording
OT  - molecular layer interneuron
OT  - plasticity
OT  - sensory stimulation
EDAT- 2015/06/25 06:00
MHDA- 2015/06/25 06:01
PMCR- 2015/01/01
CRDT- 2015/06/25 06:00
PHST- 2015/04/01 00:00 [received]
PHST- 2015/05/20 00:00 [accepted]
PHST- 2015/06/25 06:00 [entrez]
PHST- 2015/06/25 06:00 [pubmed]
PHST- 2015/06/25 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2015.00214 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2015 Jun 9;9:214. doi: 10.3389/fncel.2015.00214. eCollection 
      2015.