PMID- 26107250
OWN - NLM
STAT- MEDLINE
DCOM- 20160505
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 6
DP  - 2015
TI  - Antigen-specific tolerogenic dendritic cells ameliorate the severity of murine 
      collagen-induced arthritis.
PG  - e0131152
LID - 10.1371/journal.pone.0131152 [doi]
LID - e0131152
AB  - Dendritic cells (DCs) play important roles in initiation of the pathogenic 
      processes of autoimmune disorders, such as rheumatoid arthritis (RA). Tolerogenic 
      dendritic cells (tolDCs) are generated from naive DCs and induce T cell 
      tolerance; thus, they represent a promising strategy for specific cellular 
      therapy for autoimmune diseases. In this study, we generated green fluorescent 
      protein (GFP)-labeled tolDCs and confirmed their phenotypes and biological 
      functions. We found that tolDCs suppressed the memory lymphocyte response and 
      exhibited strong tolerogenic potential; thus, these cells show promise for the 
      treatment of autoimmune diseases. Additionally, a collagen-induced arthritis 
      (CIA) mouse model was used to test the role of tolDCs in vivo. The results of a 
      further mechanistic experiment revealed that tolDCs suppressed inflammatory 
      arthritis at least partially by up-regulating regulatory T (Treg) cells. 
      Collectively, our data suggest that tolDCs may be used as a promising alternative 
      therapy for inflammatory arthritis.
FAU - Ning, Bin
AU  - Ning B
AD  - Department of Orthopedic Surgery, Jinan Central Hospital affiliated with Shandong 
      University, Jinan, Shandong, China; Department of Biological Sciences, Wichita 
      State University, Wichita, KS, United States of America.
FAU - Wei, Jianlu
AU  - Wei J
AD  - Department of Orthopedic Surgery, Jinan Central Hospital affiliated with Shandong 
      University, Jinan, Shandong, China.
FAU - Zhang, Aijun
AU  - Zhang A
AD  - Department of Pediatrics, Qilu Hospital, Shandong University, Jinan, Shandong, 
      China.
FAU - Gong, Weiming
AU  - Gong W
AD  - Department of Orthopedic Surgery, Jinan Central Hospital affiliated with Shandong 
      University, Jinan, Shandong, China.
FAU - Fu, Jinqiu
AU  - Fu J
AD  - Department of Pediatrics, Qilu Hospital, Shandong University, Jinan, Shandong, 
      China.
FAU - Jia, Tanghong
AU  - Jia T
AD  - Department of Orthopedic Surgery, Jinan Central Hospital affiliated with Shandong 
      University, Jinan, Shandong, China.
FAU - Yang, Shang-You
AU  - Yang SY
AD  - Department of Orthopedic Surgery, Jinan Central Hospital affiliated with Shandong 
      University, Jinan, Shandong, China; Department of Biological Sciences, Wichita 
      State University, Wichita, KS, United States of America.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150624
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - Arthritis, Experimental/diagnosis/*immunology
MH  - Dendritic Cells/*immunology
MH  - Immune Tolerance/*immunology
MH  - Male
MH  - Mice
MH  - Severity of Illness Index
MH  - T-Lymphocytes, Regulatory/*immunology
PMC - PMC4479586
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/06/25 06:00
MHDA- 2016/05/06 06:00
PMCR- 2015/06/24
CRDT- 2015/06/25 06:00
PHST- 2015/04/11 00:00 [received]
PHST- 2015/05/31 00:00 [accepted]
PHST- 2015/06/25 06:00 [entrez]
PHST- 2015/06/25 06:00 [pubmed]
PHST- 2016/05/06 06:00 [medline]
PHST- 2015/06/24 00:00 [pmc-release]
AID - PONE-D-15-09598 [pii]
AID - 10.1371/journal.pone.0131152 [doi]
PST - epublish
SO  - PLoS One. 2015 Jun 24;10(6):e0131152. doi: 10.1371/journal.pone.0131152. 
      eCollection 2015.