PMID- 26107380
OWN - NLM
STAT- MEDLINE
DCOM- 20160426
LR  - 20200306
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 6
DP  - 2015
TI  - High expression levels of BLyS/BAFF by blood dendritic cells and granulocytes are 
      associated with B-cell dysregulation in SIV-infected rhesus macaques.
PG  - e0131513
LID - 10.1371/journal.pone.0131513 [doi]
LID - e0131513
AB  - Dendritic cells (DCs) modulate B-cell survival and differentiation, mainly 
      through production of growth factors such as B lymphocyte stimulator (BLyS/BAFF). 
      In recent longitudinal studies involving HIV-1-infected individuals with 
      different rates of disease progression, we have shown that DCs were altered in 
      number and phenotype in the context of HIV-1 disease progression and B-cell 
      dysregulations were associated with increased BLyS/BAFF expression in plasma and 
      by blood myeloid DCs (mDCs) in rapid and classic progressors but not in 
      HIV-1-elite controllers (EC). Suggesting that the extent to which HIV-1 disease 
      progression is controlled may be linked to BLyS/BAFF expression status and the 
      capacity to orchestrate B-cell responses. Herein, longitudinal analyses of simian 
      immunodeficiency virus (SIV)-infected rhesus macaques also revealed increased 
      expression of BLyS/BAFF by blood mDCs as soon as day 8 and throughout infection. 
      Strikingly, granulocytes presented the highest BLyS/BAFF expression profile in 
      the blood of SIV-infected macaques. BLyS/BAFF levels were also increased in 
      plasma and correlated with viral loads. Consequently, these SIV-infected animals 
      had plasma hyperglobulinemia and reduced blood B-cell numbers with altered 
      population frequencies. These data underscore that BLyS/BAFF is associated with 
      immune dysregulation in SIV-infected rhesus macaques and suggest that BLyS/BAFF 
      is a key regulator of immune activation that is highly conserved among primates. 
      These findings emphasize the potential importance of this SIV-infected primate 
      model to test whether blocking excess BLyS/BAFF has an effect on the overall 
      inflammatory burden and immune restoration.
FAU - Poudrier, Johanne
AU  - Poudrier J
AD  - Laboratoire d'immunogenetique, Centre de Recherche du Centre Hospitalier de 
      l'Universite de Montreal (CRCHUM), Montreal, Canada; Departement de 
      Microbiologie, Infectiologie et Immunologie de l'Universite de Montreal, 
      Montreal, Canada.
FAU - Soulas, Caroline
AU  - Soulas C
AD  - Boston College, Boston, MA, United States of America.
FAU - Chagnon-Choquet, Josiane
AU  - Chagnon-Choquet J
AD  - Laboratoire d'immunogenetique, Centre de Recherche du Centre Hospitalier de 
      l'Universite de Montreal (CRCHUM), Montreal, Canada; Departement de 
      Microbiologie, Infectiologie et Immunologie de l'Universite de Montreal, 
      Montreal, Canada.
FAU - Burdo, Tricia
AU  - Burdo T
AD  - Boston College, Boston, MA, United States of America.
FAU - Autissier, Patrick
AU  - Autissier P
AD  - Boston College, Boston, MA, United States of America.
FAU - Oskar, Kathryn
AU  - Oskar K
AD  - Boston College, Boston, MA, United States of America.
FAU - Williams, Kenneth C
AU  - Williams KC
AD  - Boston College, Boston, MA, United States of America.
FAU - Roger, Michel
AU  - Roger M
AD  - Laboratoire d'immunogenetique, Centre de Recherche du Centre Hospitalier de 
      l'Universite de Montreal (CRCHUM), Montreal, Canada; Departement de 
      Microbiologie, Infectiologie et Immunologie de l'Universite de Montreal, 
      Montreal, Canada.
LA  - eng
GR  - R01 NS040237/NS/NINDS NIH HHS/United States
GR  - R01 NS082116/NS/NINDS NIH HHS/United States
GR  - R01NS40237/NS/NINDS NIH HHS/United States
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150624
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (B-Cell Activating Factor)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Animals
MH  - B-Cell Activating Factor/*blood
MH  - B-Lymphocytes/*cytology/virology
MH  - CD4-Positive T-Lymphocytes/cytology/virology
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Dendritic Cells/*cytology/virology
MH  - Disease Progression
MH  - Flow Cytometry
MH  - Granulocytes/*cytology/virology
MH  - Immunoglobulin G/immunology
MH  - Immunoglobulin M/immunology
MH  - Inflammation
MH  - Macaca mulatta
MH  - Male
MH  - Phenotype
MH  - Simian Acquired Immunodeficiency Syndrome/*blood/virology
MH  - Simian Immunodeficiency Virus
MH  - Viral Load
PMC - PMC4479440
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/06/25 06:00
MHDA- 2016/04/27 06:00
PMCR- 2015/06/24
CRDT- 2015/06/25 06:00
PHST- 2015/04/07 00:00 [received]
PHST- 2015/06/03 00:00 [accepted]
PHST- 2015/06/25 06:00 [entrez]
PHST- 2015/06/25 06:00 [pubmed]
PHST- 2016/04/27 06:00 [medline]
PHST- 2015/06/24 00:00 [pmc-release]
AID - PONE-D-15-15074 [pii]
AID - 10.1371/journal.pone.0131513 [doi]
PST - epublish
SO  - PLoS One. 2015 Jun 24;10(6):e0131513. doi: 10.1371/journal.pone.0131513. 
      eCollection 2015.