PMID- 26108070
OWN - NLM
STAT- MEDLINE
DCOM- 20160328
LR  - 20161020
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 36
IP  - 4
DP  - 2015 Jul-Aug
TI  - Effect of solar irradiation on serum specific immunoglobulin E to house-dust 
      mite.
PG  - 44-50
LID - 10.2500/aap.2015.36.3845 [doi]
AB  - BACKGROUND: The relationship between sensitization to Dermatophagoides species 
      and solar irradiation, as reflected by vitamin D, remains elusive. OBJECTIVE: We 
      investigated the lag time and the cumulative and maximum effects of exposure to 
      solar irradiation on sensitization to house-dust mites. METHODS: A time series 
      study design was applied to solar irradiation (MJ/m(2)) and relative humidity (%) 
      for specific immunoglobulin E (IgE) levels against Dermatophagoides pteronyssinus 
      (n = 20,451) and Dermatophagoides farinae (n = 22,824). We used the distributed 
      lag nonlinear model to assess the difference of log IgE to house-dust mites in 
      relation to climate variables. RESULTS: Compared with specific IgE levels of 
      those exposed to 18 MJ/m(2), the maximum increase in sensitization to D. 
      pteronyssinus was observed at a solar irradiation of 10 MJ/m(2) at peak 0 week 
      (difference of log IgE 0.368 [95% confidence interval (CI), 0.209-0.529], p < 
      0.001), and this increase continued for 3 weeks. The IgE level was significantly 
      affected by the relative humidity of the 3rd- to 12th-lag week, and the effect 
      reached its peak at 75% on the 8th week (difference of log IgE 0.394 [95% CI, 
      0.221-0.566], p < 0.001). The logistic regression analysis showed that solar 
      irradiation was associated with a decreased risk to sensitization to D. 
      pteronyssinus (odds ratio 0.988 per 1 MJ/m(2) [95% CI, 0.979-0.997], p < 0.013) 
      on the testing week after controlling for humidity and temperature. CONCLUSION: 
      This study demonstrated that low solar irradiation immediately increased the risk 
      of sensitization to two house-dust mite species. Further research is warranted to 
      delineate the underlying mechanism of the effect of solar irradiation on 
      aeroallergen sensitization.
FAU - Lee, Seung Won
AU  - Lee SW
AD  - CHA University School of Medicine, Seongnam, Korea.
FAU - Cho, Eunhae
AU  - Cho E
FAU - Koh, Hyun Yong
AU  - Koh HY
FAU - Shin, Jihyun
AU  - Shin J
FAU - Baek, Ji Hyeon
AU  - Baek JH
FAU - Shin, Youn Ho
AU  - Shin YH
FAU - Jee, Hye Mi
AU  - Jee HM
FAU - Kim, Hyo-Mi
AU  - Kim HM
FAU - Han, Man Yong
AU  - Han MY
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Antigens, Dermatophagoides)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Antigens, Dermatophagoides/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Climate
MH  - Female
MH  - Humans
MH  - Hypersensitivity/epidemiology/immunology
MH  - Immunoglobulin E/blood/*immunology
MH  - Male
MH  - Middle Aged
MH  - Population Surveillance
MH  - Pyroglyphidae/*immunology
MH  - Republic of Korea/epidemiology
MH  - Seasons
MH  - *Sunlight
MH  - Young Adult
EDAT- 2015/06/25 06:00
MHDA- 2016/03/29 06:00
CRDT- 2015/06/25 06:00
PHST- 2015/06/25 06:00 [entrez]
PHST- 2015/06/25 06:00 [pubmed]
PHST- 2016/03/29 06:00 [medline]
AID - 10.2500/aap.2015.36.3845 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2015 Jul-Aug;36(4):44-50. doi: 10.2500/aap.2015.36.3845.