PMID- 26108134
OWN - NLM
STAT- MEDLINE
DCOM- 20160620
LR  - 20220408
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 37
IP  - 7
DP  - 2015 Aug
TI  - Proton pump inhibitors linked to hypomagnesemia: a systematic review and 
      meta-analysis of observational studies.
PG  - 1237-41
LID - 10.3109/0886022X.2015.1057800 [doi]
AB  - BACKGROUND: The reported risk of hypomagnesemia in patients with proton pump 
      inhibitor (PPI) use is conflicting. The objective of this meta-analysis was to 
      assess the association between the use of PPIs and the risk of hypomagnesemia. 
      METHODS: A literature search of observational studies was performed using 
      MEDLINE, EMBASE and Cochrane Database of Systematic Reviews from inception 
      through September 2014. Studies that reported odd ratios or hazard ratios 
      comparing the risk of hypomagnesemia in patients with PPI use were included. 
      Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated using a 
      random-effect, generic inverse variance method. RESULTS: Nine observational 
      studies (three cohort studies, five cross-sectional studies and a case-control 
      study) with a total of 109,798 patients were identified and included in the data 
      analysis. The pooled RR of hypomagnesemia in patients with PPI use was 1.43 (95% 
      CI, 1.08-1.88). The association between the use of PPIs and hypomagnesemia 
      remained significant after the sensitivity analysis including only studies with 
      high quality score (Newcastle-Ottawa scale score >/= 8) with a pooled RR of 1.63 
      (95% CI, 1.14-2.23). CONCLUSIONS: Our study demonstrates a statistically 
      significant increased risk of hypomagnesemia in patients with PPI use. The 
      finding of this meta-analysis of observational studies suggests that PPI use is 
      associated with hypomagnesemia and may impact clinical management of patients who 
      are taking PPIs and at risk for hypomagnesemia related cardiovascular events.
FAU - Cheungpasitporn, Wisit
AU  - Cheungpasitporn W
AD  - a Division of Nephrology and Hypertension , Mayo Clinic , Rochester , MN , USA .
FAU - Thongprayoon, Charat
AU  - Thongprayoon C
AD  - a Division of Nephrology and Hypertension , Mayo Clinic , Rochester , MN , USA .
FAU - Kittanamongkolchai, Wonngarm
AU  - Kittanamongkolchai W
AD  - a Division of Nephrology and Hypertension , Mayo Clinic , Rochester , MN , USA .
FAU - Srivali, Narat
AU  - Srivali N
AD  - b Division of Pulmonary and Critical Care Medicine , Mayo Clinic , Rochester , MN 
      , USA .
FAU - Edmonds, Peter J
AU  - Edmonds PJ
AD  - c Department of Medicine , SUNY Upstate Medical University , Syracuse , NY , USA 
      .
FAU - Ungprasert, Patompong
AU  - Ungprasert P
AD  - d Division of Rheumatology , Mayo Clinic , Rochester , MN , USA .
FAU - O'Corragain, Oisin A
AU  - O'Corragain OA
AD  - e Department of Medicine , University College Cork , Cork , Ireland , and.
FAU - Korpaisarn, Sira
AU  - Korpaisarn S
AD  - f Department of Medicine , MetroWest Medical Center , Framingham , MA , USA.
FAU - Erickson, Stephen B
AU  - Erickson SB
AD  - a Division of Nephrology and Hypertension , Mayo Clinic , Rochester , MN , USA .
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20150625
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 0 (Proton Pump Inhibitors)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Humans
MH  - Magnesium/*blood
MH  - Observational Studies as Topic
MH  - Odds Ratio
MH  - Proton Pump Inhibitors/*adverse effects/therapeutic use
MH  - Publication Bias
OTO - NOTNLM
OT  - Electrolyte
OT  - hypomagnesemia
OT  - magnesium
OT  - meta-analysis
OT  - proton pump inhibitors
EDAT- 2015/06/26 06:00
MHDA- 2016/06/21 06:00
CRDT- 2015/06/26 06:00
PHST- 2015/06/26 06:00 [entrez]
PHST- 2015/06/26 06:00 [pubmed]
PHST- 2016/06/21 06:00 [medline]
AID - 10.3109/0886022X.2015.1057800 [doi]
PST - ppublish
SO  - Ren Fail. 2015 Aug;37(7):1237-41. doi: 10.3109/0886022X.2015.1057800. Epub 2015 
      Jun 25.