PMID- 26108589
OWN - NLM
STAT- MEDLINE
DCOM- 20161107
LR  - 20221213
IS  - 1658-3175 (Electronic)
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 36
IP  - 7
DP  - 2015 Jul
TI  - Hyperhomocysteinemia as a metabolic disorder parameter is independently 
      associated with the severity of coronary heart disease.
PG  - 839-46
LID - 10.15537/smj.2015.7.11453 [doi]
AB  - OBJECTIVES: To study the associations between hyperhomocysteinemia (HHcy) and the 
      severity of coronary heart disease (CHD). METHODS: We retrospectively analyzed 
      metabolic parameters, anthropometric variables, and life style habits in 292 CHD 
      patients of different categories, and 100 controlled non-CHD patients with chest 
      pain symptoms who were hospitalized in the Department of Cardiovascular Medicine, 
      Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, 
      Chengdu, China between October 2013 and September 2014. RESULTS: The prevalence 
      of HHcy in CHD patients was 79.1%, while only 5% of non-CHD patients had elevated 
      serum homocysteine (Hcy) concentrations. The prevalence of HHcy significantly 
      increased from 5% in non-CHD controls to 66% in the stable angina pectoris (SAP) 
      group, to 81.9% in the unstable angina pectoris group, and to 93.15% in the acute 
      myocardial infarction (AMI) group (p less than 0.001). After adjusting for 
      confounding factors, multivariate logistic regression analysis showed that HHcy 
      was independently associated with CHD category (AMI versus SAP, odds ratio 
      [6.38], 95% confidence interval; 1.18-34.46). The Hcy was negatively correlated 
      with folic acid (r=-0.67, p less than 0.001) and vitamin B12 (r=-0.56, p less 
      than 0.001). Of the CHD patients with HHcy, 51.1% had low folic acid and 42% had 
      low vitamin B12, 7 or 5 times higher than that of CHD patients with normal-low 
      Hcy concentrations (p less than 0.001). CONCLUSION: Hyperhomocysteinemia is 
      independently associated with the severity of CHD, and significantly correlated 
      with low status of folic acid and vitamin B12 in CHD patients.
FAU - Liu, Chenggui
AU  - Liu C
AD  - Department of Clinical Laboratory, Chengdu Women's and Children's Central 
      Hospital, Chongqing Medical University, Chengdu, China. E-mail. lablcg@126.com.
FAU - Yang, Yinzhong
AU  - Yang Y
FAU - Peng, Duanliang
AU  - Peng D
FAU - Chen, Linong
AU  - Chen L
FAU - Luo, Jun
AU  - Luo J
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Coronary Artery Disease/*complications
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/*complications
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
PMC - PMC4503904
EDAT- 2015/06/26 06:00
MHDA- 2016/11/08 06:00
PMCR- 2015/07/01
CRDT- 2015/06/26 06:00
PHST- 2015/06/26 06:00 [entrez]
PHST- 2015/06/26 06:00 [pubmed]
PHST- 2016/11/08 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - SaudiMedJ-36-839 [pii]
AID - 10.15537/smj.2015.7.11453 [doi]
PST - ppublish
SO  - Saudi Med J. 2015 Jul;36(7):839-46. doi: 10.15537/smj.2015.7.11453.