PMID- 2610944
OWN - NLM
STAT- MEDLINE
DCOM- 19900306
LR  - 20180608
IS  - 0895-3988 (Print)
IS  - 0895-3988 (Linking)
VI  - 2
IP  - 3
DP  - 1989 Sep
TI  - Disposition and metabolism of 1-nitropropane in rats and chimpanzees.
PG  - 249-64
AB  - The metabolic fate of 1-nitropropane (1-NP) has not been previously reported. In 
      this study male rats and chimpanzees were given single doses of 40 mg/kg ip and 5 
      mg/kg iv 1-[1-14C]NP, respectively. The quantitative extent of urinary and fecal 
      elimination was similar in both species. The rats excreted 16.5% of the dose in 
      urine and 1.7% in feces. For chimpanzees the respective values were 14.8 and 
      1.2%. Experiments with rats demonstrated that the major route of elimination was 
      by exhalation. With a total elimination via the lungs of 72.6%, rats expired 
      10.3% of the dose as unchanged 1-NP. Five polar metabolites were isolated from 
      the urine of chimpanzees. The two major metabolites were identified as 
      3-hydroxypropionic acid and N-methyl-N-2-(methylsulfinyl)ethylpropionic acid 
      amide (NMPA). Both substances were also excreted in rat urine. The two identified 
      metabolites indicate that 1-NP was degraded to propionic acid, part of which was 
      modified to 3-hydroxypropionic acid or NMPA. A hypothetical pathway for the 
      biochemical generation of NMPA is suggested.
FAU - Haas-Jobelius, M
AU  - Haas-Jobelius M
AD  - Gesellschaft fur Strahlen- und Umweltforschung mbH Munchen, Institut fur 
      Okologische Chemie, Neuherberg, Federal Republic of Germany.
FAU - Korte, F
AU  - Korte F
FAU - Coulston, F
AU  - Coulston F
LA  - eng
PT  - Journal Article
PL  - China
TA  - Biomed Environ Sci
JT  - Biomedical and environmental sciences : BES
JID - 8909524
RN  - 0 (Alkanes)
RN  - 0 (Amides)
RN  - 0 (Lactates)
RN  - 0 (Nitroparaffins)
RN  - 0 (Propionates)
RN  - 137915-12-9 (N-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 39W305OW99 (1-nitropropane)
RN  - C4ZF6XLD2X (hydracrylic acid)
RN  - T75W9911L6 (Propane)
SB  - IM
MH  - Alkanes/*pharmacokinetics
MH  - Amides/metabolism
MH  - Animals
MH  - Chromatography
MH  - Chromatography, High Pressure Liquid
MH  - Feces/analysis
MH  - Lactates/metabolism
MH  - *Lactic Acid/*analogs & derivatives
MH  - Lung/metabolism
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Mass Spectrometry
MH  - Nitroparaffins/*pharmacokinetics/urine
MH  - Pan troglodytes
MH  - Propane/*analogs & derivatives/pharmacokinetics/urine
MH  - Propionates/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tissue Distribution
EDAT- 1989/09/01 00:00
MHDA- 1989/09/01 00:01
CRDT- 1989/09/01 00:00
PHST- 1989/09/01 00:00 [pubmed]
PHST- 1989/09/01 00:01 [medline]
PHST- 1989/09/01 00:00 [entrez]
PST - ppublish
SO  - Biomed Environ Sci. 1989 Sep;2(3):249-64.