PMID- 26110387
OWN - NLM
STAT- MEDLINE
DCOM- 20160405
LR  - 20220317
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 16
IP  - 6
DP  - 2015 Jun 23
TI  - A Plasmacytoid Dendritic Cells-Type I Interferon Axis Is Critically Implicated in 
      the Pathogenesis of Systemic Lupus Erythematosus.
PG  - 14158-70
LID - 10.3390/ijms160614158 [doi]
AB  - Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that is 
      characterized by the generation of immune responses to various nuclear 
      components. Impaired clearance of apoptotic cells and loss of tolerance to 
      self-antigens are involved both in the initiation and in the propagation of the 
      disease. Dendritic cells (DCs) are key factors in the balance between 
      autoimmunity and tolerance and play a role linking innate and adaptive immunity. 
      DCs, particularly plasmacytoid DCs (pDCs), are the main source of type I 
      interferon (IFN) cytokines, which contribute to the immunopathogenesis of SLE. 
      There is accumulating evidence that pDCs and type I IFN cytokines take the 
      leading part in the development of SLE. In this review, we discuss recent data 
      regarding the role of pDCs and type I IFN cytokines in the pathogenesis of SLE 
      and the potential for employing therapies targeting against aberrant regulation 
      of the pDC-type I IFN axis for treating SLE.
FAU - Kim, Ji-Min
AU  - Kim JM
AD  - Division of Rheumatology, Department of Internal Medicine, Dongsan Medical 
      Center, Keimyung University School of Medicine, Daegu 700-712, Korea. 
      okjimin@hanmail.net.
FAU - Park, Sung-Hwan
AU  - Park SH
AD  - Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, 
      Korea. rapark@catholic.ac.kr.
FAU - Kim, Ho-Youn
AU  - Kim HY
AD  - Division of Rheumatology, Department of Internal Medicine, Konkuk University 
      Medical Center, Seoul 143-729, Korea. ho0919@gmail.com.
FAU - Kwok, Seung-Ki
AU  - Kwok SK
AD  - Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, 
      Korea. seungki73@catholic.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150623
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Interferon Type I)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/metabolism/*pathology
MH  - Humans
MH  - Interferon Type I/*metabolism
MH  - Lupus Erythematosus, Systemic/metabolism/*pathology
PMC - PMC4490545
OTO - NOTNLM
OT  - dendritic cells
OT  - systemic lupus erythematosus
OT  - type I interferon
EDAT- 2015/06/26 06:00
MHDA- 2016/04/06 06:00
PMCR- 2015/06/01
CRDT- 2015/06/26 06:00
PHST- 2015/04/21 00:00 [received]
PHST- 2015/06/01 00:00 [revised]
PHST- 2015/06/16 00:00 [accepted]
PHST- 2015/06/26 06:00 [entrez]
PHST- 2015/06/26 06:00 [pubmed]
PHST- 2016/04/06 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - ijms160614158 [pii]
AID - ijms-16-14158 [pii]
AID - 10.3390/ijms160614158 [doi]
PST - epublish
SO  - Int J Mol Sci. 2015 Jun 23;16(6):14158-70. doi: 10.3390/ijms160614158.