PMID- 26113081
OWN - NLM
STAT- MEDLINE
DCOM- 20170515
LR  - 20171128
IS  - 1423-0194 (Electronic)
IS  - 0028-3835 (Linking)
VI  - 103
IP  - 3-4
DP  - 2016
TI  - Bronchopulmonary Neuroendocrine Neoplasms and Their Precursor Lesions in Multiple 
      Endocrine Neoplasia Type 1.
PG  - 240-7
LID - 10.1159/000435921 [doi]
AB  - OBJECTIVE: The prevalence and clinical behavior of bronchopulmonary 
      neuroendocrine tumors (bNET) associated with multiple endocrine neoplasia type 1 
      (MEN1) are not well defined. This study aimed to determine the prevalence, 
      potential precursor lesions and prognosis of bNET in patients with MEN1. METHODS: 
      A database of 75 prospectively collected MEN1 cases was retrospectively analyzed 
      for bNET. Patient characteristics, imaging and treatment were evaluated. 
      Resection specimens of operated patients were reassessed by two specialized 
      pathologists. Available CT scans of the whole cohort were reviewed to determine 
      the prevalence of bronchopulmonary nodules. RESULTS: Five of the 75 MEN1 patients 
      (6.6%; 2 male, 3 female) developed histologically confirmed bNET after a median 
      follow-up of 134 months. The median age at diagnosis of bNET was 47 years (range 
      31-67), and all patients were asymptomatic. Four patients underwent anatomic lung 
      resections with lymphadenectomy; the remaining patient with multiple lesions had 
      only a wedge resection of the largest bNET. Tumor sizes ranged from 7 to 32 mm in 
      diameter, and all bNET were well differentiated. Two patients had lymph node 
      metastases. Two of 4 reevaluated resection specimens revealed multifocal bNET, 
      and 3 specimens showed tumorlets (up to 3) associated with multifocal areas of a 
      neuroendocrine cell hyperplasia within the subsegmental bronchi. One bNET-related 
      death (1.3%) occurred during long-term follow-up. Review of the available CT 
      scans of the patients without proven bNET revealed small bronchopulmonary lesions 
      (>/=3 mm) in 16 of 53 cases (30.2%). CONCLUSIONS: bNET in MEN1 might be more common 
      than previously recognized. Their natural course seems to be rather benign. 
      Multifocal tumorlets and multifocal neuroendocrine cell hyperplasia might 
      represent their precursor lesions.
CI  - (c) 2015 S. Karger AG, Basel.
FAU - Bartsch, Detlef K
AU  - Bartsch DK
AD  - Department of Visceral, Thoracic and Vascular Surgery, Philipps-Universitx00E4;t 
      Marburg, Marburg, Germany.
FAU - Albers, Max B
AU  - Albers MB
FAU - Lopez, Caroline L
AU  - Lopez CL
FAU - Apitzsch, Jonas C
AU  - Apitzsch JC
FAU - Walthers, Eduard M
AU  - Walthers EM
FAU - Fink, Ludger
AU  - Fink L
FAU - Fendrich, Volker
AU  - Fendrich V
FAU - Slater, Emily P
AU  - Slater EP
FAU - Waldmann, Jens
AU  - Waldmann J
FAU - Anlauf, Martin
AU  - Anlauf M
LA  - eng
PT  - Journal Article
DEP - 20150618
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bronchial Neoplasms/*complications/diagnostic imaging/*epidemiology/pathology
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*complications/*epidemiology/pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/diagnostic 
      imaging/*epidemiology/pathology/surgery
MH  - Neuroendocrine Tumors/diagnostic imaging/pathology/surgery
MH  - Tomography, Emission-Computed
EDAT- 2015/06/27 06:00
MHDA- 2017/05/16 06:00
CRDT- 2015/06/27 06:00
PHST- 2014/11/04 00:00 [received]
PHST- 2015/06/10 00:00 [accepted]
PHST- 2015/06/27 06:00 [entrez]
PHST- 2015/06/27 06:00 [pubmed]
PHST- 2017/05/16 06:00 [medline]
AID - 000435921 [pii]
AID - 10.1159/000435921 [doi]
PST - ppublish
SO  - Neuroendocrinology. 2016;103(3-4):240-7. doi: 10.1159/000435921. Epub 2015 Jun 
      18.