PMID- 26115285
OWN - NLM
STAT- MEDLINE
DCOM- 20160309
LR  - 20231213
IS  - 1525-3163 (Electronic)
IS  - 0021-8812 (Linking)
VI  - 93
IP  - 6
DP  - 2015 Jun
TI  - Effects of dietary soybean meal concentration on growth and immune response of 
      pigs infected with porcine reproductive and respiratory syndrome virus.
PG  - 2987-97
LID - 10.2527/jas.2014-8462 [doi]
AB  - An experiment was conducted to determine the effects of dietary soybean meal 
      (SBM) concentration on the growth performance and immune response of pigs 
      infected with porcine reproductive and respiratory syndrome virus (PRRSV). Four 
      experimental treatments included a 2 x 2 factorial arrangement of 2 dietary SBM 
      concentrations, 17.5% (LSBM) or 29% (HSBM), and 2 levels of PRRSV infection, 
      uninfected sham or PRRSV infected. Sixty-four weanling pigs of split sex (21 d of 
      age, 7.14 +/- 0.54 kg) were individually housed in disease containment chambers. 
      Pigs were provided a common diet for 1 wk postweaning before being equalized for 
      BW and sex and allotted to 4 treatment groups with 16 replicate pigs per group. 
      Pigs were fed experimental diets for 1 wk before receiving either a sham 
      inoculation (sterile PBS) or a 1 x 10 50% tissue culture infective dose of PRRSV 
      at 35 d of age (0 d postinoculation, DPI). Pig BW and feed intake were recorded 
      weekly, and rectal temperatures were measured daily beginning on 0 DPI. Blood was 
      collected on 0, 3, 7, and 14 DPI for determination of serum PRRSV load, 
      differential complete blood cell counts, and haptoglobin and cytokine 
      concentrations. Infection with PRRSV increased (P < 0.01) rectal temperatures of 
      pigs throughout the infection period, with no influence of dietary SBM 
      concentration. Pigs in the PRRSV-infected group had lower (P < 0.01) ADFI and G:F 
      from 0 to 14 DPI compared with uninfected pigs. In the PRRSV-infected group, pigs 
      fed HSBM tended to have improved ADG (P = 0.06) compared with pigs fed LSBM, 
      whereas there was no influence of SBM concentration on growth of pigs in the 
      uninfected group. At 14 DPI, PRRSV-infected pigs fed HSBM had a lower serum PRRSV 
      load (P < 0.05), a higher (P = 0.02) hematocrit value, and a tendency for greater 
      hemoglobin concentration (P = 0.09) compared with pigs fed LSBM. Serum 
      haptoglobin and tumor necrosis factor-alpha concentrations of PRRSV-infected pigs 
      were lower (P < 0.05) in pigs fed HSBM at 3 and 14 DPI, respectively, than in 
      pigs fed LSBM. Overall, increasing the dietary SBM concentration modulated the 
      immune response and tended to improve the growth of nursery pigs during a PRRSV 
      infection.
FAU - Rochell, S J
AU  - Rochell SJ
FAU - Alexander, L S
AU  - Alexander LS
FAU - Rocha, G C
AU  - Rocha GC
FAU - Van Alstine, W G
AU  - Van Alstine WG
FAU - Boyd, R D
AU  - Boyd RD
FAU - Pettigrew, J E
AU  - Pettigrew JE
FAU - Dilger, R N
AU  - Dilger RN
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
RN  - 0 (Antibodies, Viral)
RN  - 0 (Cytokines)
SB  - IM
MH  - Animal Feed/*analysis
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Cytokines/blood
MH  - Diet/*veterinary
MH  - Female
MH  - Male
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - *Glycine max
MH  - Swine
EDAT- 2015/06/27 06:00
MHDA- 2016/03/10 06:00
CRDT- 2015/06/27 06:00
PHST- 2015/06/27 06:00 [entrez]
PHST- 2015/06/27 06:00 [pubmed]
PHST- 2016/03/10 06:00 [medline]
AID - 10.2527/jas.2014-8462 [doi]
PST - ppublish
SO  - J Anim Sci. 2015 Jun;93(6):2987-97. doi: 10.2527/jas.2014-8462.