PMID- 26115442 OWN - NLM STAT- MEDLINE DCOM- 20160706 LR - 20220129 IS - 1529-8027 (Electronic) IS - 1085-9489 (Linking) VI - 20 IP - 3 DP - 2015 Sep TI - Outcome measures in MMN revisited: further improvement needed. PG - 306-18 LID - 10.1111/jns.12124 [doi] AB - The objectives of this study were to provide an overview of the outcome measures (OMs) applied in clinical trials in multifocal motor neuropathy (MMN) and to determine the responsiveness of a core set of selected OMs as part of the peripheral neuropathy outcome measures standardization (PeriNomS) study. The following OMs were serially applied in 26 patients with newly diagnosed or relapsing MMN, receiving intravenous immunoglobulin (assessments: T0/T3/T12 months): 14 muscle pairs MRC (Medical Research Council) scale, the Neuropathy Impairment Scale motor-subset, a self-evaluation scale, grip strength, and MMN-RODS(c) (Rasch-built overall disability scale). All data, except the grip strength, were subjected to Rasch analyses before determining responsiveness. For grip strength, responsiveness was examined using a combined anchor- (SF-36 question-2) and distribution-based ((1/2) x SD) minimum clinically important difference (MCID) techniques, determining the proportion of patients exceeding both the identified cut-offs. For the remaining scales, the magnitude of change for each patient on each scale was determined using the MCID related to the individual SE (responder definition: MCID-SE >/= 1.96). Overall, a great assortment of measures has been used in MMN trials with different responsiveness definitions. For the selected OMs, responsiveness was poor and only seen in one fourth to one third of the patients, the grip strength being more responsive. Despite the efforts taken to standardize outcome assessment, further clinimetric responsiveness studies are needed in MMN. CI - (c) 2015 Peripheral Nerve Society. FAU - Pruppers, Marielle H J AU - Pruppers MH AD - Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands. FAU - Draak, Thomas H P AU - Draak TH AD - Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands. FAU - Vanhoutte, Els K AU - Vanhoutte EK AD - Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands. FAU - Van der Pol, W-Ludo AU - Van der Pol WL AD - Department of Neurology, Rudolf Magnus Institute of Neuroscience University Medical Center, Utrecht, The Netherlands. FAU - Gorson, Kenneth C AU - Gorson KC AD - Department of Neurology, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA. FAU - Leger, Jean-Marc AU - Leger JM AD - Department of Neurology, Hopital de la Salpetriere, Paris, France. FAU - Nobile-Orazio, Eduardo AU - Nobile-Orazio E AD - Department of Neurological Sciences, Milan University, Humanitas Clinical Institute, Rozzano, Milan, Italy. FAU - Lewis, Richard A AU - Lewis RA AD - Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA. FAU - van den Berg, Leonard H AU - van den Berg LH AD - Department of Neurology, Rudolf Magnus Institute of Neuroscience University Medical Center, Utrecht, The Netherlands. FAU - Faber, Catharina G AU - Faber CG AD - Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands. FAU - Merkies, Ingemar S J AU - Merkies IS AD - Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands. AD - Department of Neurology, Spaarne Hospital, Hoofddorp, The Netherlands. CN - PeriNomS study group LA - eng GR - MR/K000608/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - J Peripher Nerv Syst JT - Journal of the peripheral nervous system : JPNS JID - 9704532 RN - 0 (Immunoglobulins, Intravenous) RN - 0 (Immunologic Factors) SB - IM MH - Adult MH - Aged MH - Databases, Bibliographic/statistics & numerical data MH - *Disability Evaluation MH - Female MH - Humans MH - Immunoglobulins, Intravenous/*therapeutic use MH - Immunologic Factors/*therapeutic use MH - Male MH - Middle Aged MH - *Outcome Assessment, Health Care MH - Polyneuropathies/*drug therapy OTO - NOTNLM OT - MMN OT - outcome measure FIR - Barreira, A A IR - Barreira AA FIR - Bennett, D IR - Bennett D FIR - Hadden, R D IR - Hadden RD FIR - Hughes, R A C IR - Hughes RA FIR - Lunn, M P T IR - Lunn MP FIR - Reilly, M M IR - Reilly MM FIR - van den Berg, L H IR - van den Berg LH FIR - van Doorn, P A IR - van Doorn PA FIR - Faber, C G IR - Faber CG FIR - van der Kooi, A J IR - van der Kooi AJ FIR - Merkies, I S J IR - Merkies IS FIR - Notermans, N C IR - Notermans NC FIR - Raaphorts, J IR - Raaphorts J FIR - van Schaik, I N IR - van Schaik IN FIR - de Visser, M IR - de Visser M FIR - Cats, E A IR - Cats EA FIR - Van den Bergh, P Y K IR - Van den Bergh PY FIR - Bombelli, F IR - Bombelli F FIR - Costa, R IR - Costa R FIR - Franques, J IR - Franques J FIR - Leger, J-M IR - Leger JM FIR - Pouget, J IR - Pouget J FIR - Bril, V IR - Bril V FIR - Hahn, A F IR - Hahn AF FIR - Katzberg, H IR - Katzberg H FIR - Campanella, A IR - Campanella A FIR - Devigili, G IR - Devigili G FIR - Gallia, F IR - Gallia F FIR - Lauria, G IR - Lauria G FIR - Nobile-Orazio, E IR - Nobile-Orazio E FIR - Padua, L IR - Padua L FIR - Cornblath, D R IR - Cornblath DR FIR - Gorson, K C IR - Gorson KC FIR - Lewis, R A IR - Lewis RA FIR - Illa, I IR - Illa I FIR - Querol, L IR - Querol L FIR - van Nes, S I IR - van Nes SI EDAT- 2015/06/27 06:00 MHDA- 2016/07/07 06:00 CRDT- 2015/06/27 06:00 PHST- 2014/11/18 00:00 [received] PHST- 2015/04/23 00:00 [revised] PHST- 2015/06/10 00:00 [accepted] PHST- 2015/06/27 06:00 [entrez] PHST- 2015/06/27 06:00 [pubmed] PHST- 2016/07/07 06:00 [medline] AID - 10.1111/jns.12124 [doi] PST - ppublish SO - J Peripher Nerv Syst. 2015 Sep;20(3):306-18. doi: 10.1111/jns.12124.