PMID- 26116517
OWN - NLM
STAT- MEDLINE
DCOM- 20160418
LR  - 20150716
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 301
DP  - 2015 Aug 20
TI  - Striking differences in synaptic facilitation along the dorsoventral axis of the 
      hippocampus.
PG  - 454-70
LID - S0306-4522(15)00570-9 [pii]
LID - 10.1016/j.neuroscience.2015.06.029 [doi]
AB  - Hippocampus displays functional heterogeneity along its long axis which has been 
      interpreted in terms of segregation of inputs. Recent evidence has shown that 
      there are also important differences in the organization of the local neuronal 
      circuitry between the dorsal (DH) and the ventral hippocampus (VH). Synaptic 
      plasticity is a crucial factor for the function of the hippocampal circuit. In 
      this study I compared the synaptic facilitation of the CA1 excitatory 
      postsynaptic potential (EPSP) between dorsal and ventral rat hippocampal slices 
      using field recordings and paired-pulse stimulation delivered at varying 
      inter-pulse intervals (IPIs). The facilitation of the EPSP-slope displayed an 
      exponential decline with increasing stimulation strength or IPI. Furthermore, the 
      facilitation of threshold EPSP-slope was significantly higher in DH than in VH at 
      all IPIs. Most remarkably, the facilitation of the area of EPSP displayed a 
      prominent peak at around 200ms in DH but not VH. This optimal facilitation 
      declined abruptly at a position located two thirds of the way along the 
      dorsoventral axis. N-methyl-d-aspartic acid receptors (NMDARs) contributed to the 
      facilitation of EPSP-area in an IPI-selective manner in DH but not VH. 
      Furthermore, NMDARs participated to the single-pulse-evoked EPSP-area more in VH 
      than in DH. Blockade of GABAB receptors (GABABRs) eliminated the prominent 
      facilitation at around 200ms and abolished the large dorsoventral difference in 
      the facilitation of EPSP-area. Blockade of GABAA receptors (GABAARs) increased 
      the maximum area of EPSP more in VH than in DH and reversed facilitation into 
      GABABR-dependent depression that was more robust in DH than in VH. I conclude 
      that interactions between the synaptic actions of GABABR, GABAAR, and NMDAR 
      contribute to diversifying short-term synaptic plasticity along the dorsoventral 
      axis of the hippocampus. It is hypothesized that this diversification has 
      important implications for the information processing performed by the local 
      circuitries of the two hippocampal segments.
CI  - Copyright (c) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Papatheodoropoulos, C
AU  - Papatheodoropoulos C
AD  - Laboratory of Physiology, Department of Medicine, School of Health Sciences, 
      University of Patras, 26504 Rio, Greece. Electronic address: cepapath@upatras.gr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150623
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (GABA Antagonists)
SB  - IM
MH  - Animals
MH  - Biophysical Phenomena/drug effects/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Electric Stimulation
MH  - Excitatory Postsynaptic Potentials/drug effects/*physiology
MH  - GABA Antagonists/pharmacology
MH  - Hippocampus/*anatomy & histology/*physiology
MH  - In Vitro Techniques
MH  - Male
MH  - Patch-Clamp Techniques
MH  - Rats
MH  - Rats, Wistar
MH  - Statistics, Nonparametric
MH  - Time Factors
OTO - NOTNLM
OT  - NMDA receptor
OT  - dorsoventral
OT  - hippocampus
OT  - memory
OT  - synaptic plasticity
OT  - theta rhythm
EDAT- 2015/06/28 06:00
MHDA- 2016/04/19 06:00
CRDT- 2015/06/28 06:00
PHST- 2015/03/03 00:00 [received]
PHST- 2015/05/07 00:00 [revised]
PHST- 2015/06/18 00:00 [accepted]
PHST- 2015/06/28 06:00 [entrez]
PHST- 2015/06/28 06:00 [pubmed]
PHST- 2016/04/19 06:00 [medline]
AID - S0306-4522(15)00570-9 [pii]
AID - 10.1016/j.neuroscience.2015.06.029 [doi]
PST - ppublish
SO  - Neuroscience. 2015 Aug 20;301:454-70. doi: 10.1016/j.neuroscience.2015.06.029. 
      Epub 2015 Jun 23.