PMID- 26117689
OWN - NLM
STAT- MEDLINE
DCOM- 20160720
LR  - 20170802
IS  - 1873-5894 (Electronic)
IS  - 0730-725X (Linking)
VI  - 33
IP  - 9
DP  - 2015 Nov
TI  - MRI and (1)H MRS findings of hepatobilary changes and cholangiocarcinoma 
      development in hamsters infected with Opisthorchis viverrini and treated with 
      N-nitrosodimethylamine.
PG  - 1146-1155
LID - S0730-725X(15)00167-8 [pii]
LID - 10.1016/j.mri.2015.06.022 [doi]
AB  - 3 T MRI and (1)H MRS were useful for quantitative investigation of the serial 
      development of hepatobiliary changes in Opisthorchis viverrini infection in 
      hamsters, and the differential diagnosis of cholangiocacinoma (CCA) development 
      from bile duct changes and normal condition is unclear. In this study, we 
      investigated the serial development of hepatobiliary changes and CCAgenesis in O. 
      viverrini-infected and N-nitrosodimethylamine (NDMA) treated hamsters (ON group) 
      using 3 T MRI and (1)H MRS and the results were compared with those either in the 
      O. viverrini-infected group (OV group) and uninfected normal controls. In the ON 
      group, CCAs were first found at 9 weeks post-infection, with sizes of ~2 mm. The 
      typical MR signal characteristics of CCA were hypo- and occasionally isointensity 
      signal on T1-weighted images, and mild-moderate to hyper-intensity signal on 
      T2-weighted images compared to the liver parenchyma. T2-weighted images with fat 
      suppression revealed dilatation of the intra- and extrahepatic bile ducts, and 
      often defined the anatomical level of biliary obstruction, cystic lesions, liver 
      abscesses, and CCA which was starting seen of these noticeable abnormalities at 5 
      weeks onwards. The results of fibrosis grading using MR images showed a positive 
      correlation (r=0.90, P<0.038 by Spearman's rank correlation test) with those of 
      the histopathological grading. In addition, 3.0 T (1)H MRS showed elevated 
      choline and decreased lipids levels in the liver tissues of the ON group. In 
      conclusion, MRI and (1)H MRS are useful for the quantitative investigation of the 
      serial development of hepatobilary changes and CCA in hamsters, and are 
      potentially useful as early diagnostic tools for CCA.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Hanpanich, Petcharakorn
AU  - Hanpanich P
AD  - Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 
      40002, Thailand; Liver Fluke and Cholangiocarcinoma Research Center, Faculty of 
      Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address: 
      pethan@kku.ac.th.
FAU - Pinlaor, Somchai
AU  - Pinlaor S
AD  - Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon 
      Kaen University, Khon Kaen 40002, Thailand; Department of Parasitology, Faculty 
      of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
FAU - Charoensuk, Lakhanawan
AU  - Charoensuk L
AD  - Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon 
      Kaen University, Khon Kaen 40002, Thailand; Department of Parasitology, Faculty 
      of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
FAU - Yongvanit, Puangrat
AU  - Yongvanit P
AD  - Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon 
      Kaen University, Khon Kaen 40002, Thailand; Department of Biochemistry, Faculty 
      of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
FAU - Chamgramol, Yaovalux
AU  - Chamgramol Y
AD  - Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon 
      Kaen University, Khon Kaen 40002, Thailand; Department of Pathology, Faculty of 
      Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
FAU - Pairojkul, Chawalit
AU  - Pairojkul C
AD  - Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon 
      Kaen University, Khon Kaen 40002, Thailand; Department of Pathology, Faculty of 
      Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
FAU - Mairiang, Eimorn
AU  - Mairiang E
AD  - Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 
      40002, Thailand.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150625
PL  - Netherlands
TA  - Magn Reson Imaging
JT  - Magnetic resonance imaging
JID - 8214883
RN  - M43H21IO8R (Dimethylnitrosamine)
SB  - IM
MH  - Animals
MH  - Bile Duct Neoplasms/drug therapy/*pathology
MH  - Bile Ducts/pathology
MH  - Cholangiocarcinoma/drug therapy/*pathology
MH  - Cricetinae
MH  - Dimethylnitrosamine/*therapeutic use
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - *Opisthorchis
MH  - *Proton Magnetic Resonance Spectroscopy
OTO - NOTNLM
OT  - Cholangiocarcinoma
OT  - Hepatobiliary change
OT  - Magnetic resonance imaging
OT  - Magnetic resonance spectroscopy
OT  - Opisthorchis viverrini
EDAT- 2015/06/29 06:00
MHDA- 2016/07/21 06:00
CRDT- 2015/06/29 06:00
PHST- 2014/08/29 00:00 [received]
PHST- 2015/04/23 00:00 [revised]
PHST- 2015/06/21 00:00 [accepted]
PHST- 2015/06/29 06:00 [entrez]
PHST- 2015/06/29 06:00 [pubmed]
PHST- 2016/07/21 06:00 [medline]
AID - S0730-725X(15)00167-8 [pii]
AID - 10.1016/j.mri.2015.06.022 [doi]
PST - ppublish
SO  - Magn Reson Imaging. 2015 Nov;33(9):1146-1155. doi: 10.1016/j.mri.2015.06.022. 
      Epub 2015 Jun 25.