PMID- 26118196
OWN - NLM
STAT- MEDLINE
DCOM- 20150817
LR  - 20191113
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 61
IP  - 5-6
DP  - 2015
TI  - Relationship between Serum Sialic Acid and Hemostatic Markers in Patients with 
      Type 2 Diabetes Mellitus.
PG  - 607-14
AB  - BACKGROUND: Serum sialic acid (SA) is an acute phase response marker. 
      Additionally, it is an independent risk factor for atherosclerotic disease and is 
      higher in patients with type 2 diabetes mellitus (T2DM). The objective of this 
      study was to determine the association of SA with blood coagulation and 
      fibrinolysis in T2DM patients. METHODS: The levels of serum SA and blood 
      coagulation and fibrinolysis markers were measured in patients with T2DM. The 
      associations of SA with hemostatic markers and other variables were assessed. 
      RESULTS: There were significant correlations between SA and fibrinogen, D-dimer, 
      factor (F) IX, and platelet (PLT) that were independent of smoking, body mass 
      index (BMI), waist-to-hip ratio, hemoglobin A(1c) (HbA1c), fasting plasma glucose 
      (FPG), triglycerides (TG), total cholesterol (TC) to high-density lipoprotein 
      cholesterol (HDL-C) ratio, and antithrombotic therapy history. Based on logistic 
      regression analyses, the highest tertile groups of fibrinogen, D-dimer, F VIII, F 
      IX, and PLT showed a significantly increased risk of high SA compared with the 
      lowest tertiles after adjusting for age, gender, and antithrombotic therapy 
      history. SA also significantly correlated with duration of diabetes, BMI, FPG, 
      TG, low-density lipoprotein cholesterol (LDL-c), TC-to-HDL-C ratio, and 
      albumin-to-creatinine ratio (ACR). CONCLUSIONS: Elevated serum SA levels are 
      associated with increased coagulability and higher risk of thrombus formation in 
      T2DM patients.
FAU - Zheng, Nengneng
AU  - Zheng N
FAU - Shi, Xinping
AU  - Shi X
FAU - Chen, Xiongwei
AU  - Chen X
FAU - Zheng, Ying
AU  - Zheng Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Biomarkers)
RN  - GZP2782OP0 (N-Acetylneuraminic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 2/*blood/physiopathology
MH  - Female
MH  - *Fibrinolysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - N-Acetylneuraminic Acid/*blood
EDAT- 2015/06/30 06:00
MHDA- 2015/08/19 06:00
CRDT- 2015/06/30 06:00
PHST- 2015/06/30 06:00 [entrez]
PHST- 2015/06/30 06:00 [pubmed]
PHST- 2015/08/19 06:00 [medline]
AID - 10.7754/clin.lab.2014.141122 [doi]
PST - ppublish
SO  - Clin Lab. 2015;61(5-6):607-14. doi: 10.7754/clin.lab.2014.141122.