PMID- 26118660
OWN - NLM
STAT- MEDLINE
DCOM- 20150928
LR  - 20210109
IS  - 1420-9071 (Electronic)
IS  - 1420-682X (Linking)
VI  - 72
IP  - 15
DP  - 2015 Aug
TI  - Connexin and pannexin signaling pathways, an architectural blueprint for CNS 
      physiology and pathology?
PG  - 2823-51
LID - 10.1007/s00018-015-1962-7 [doi]
AB  - The central nervous system (CNS) is composed of a highly heterogeneous population 
      of cells. Dynamic interactions between different compartments (neuronal, glial, 
      and vascular systems) drive CNS function and allow to integrate and process 
      information as well as to respond accordingly. Communication within this 
      functional unit, coined the neuro-glio-vascular unit (NGVU), typically relies on 
      two main mechanisms: direct cell-cell coupling via gap junction channels (GJCs) 
      and paracrine communication via the extracellular compartment, two routes to 
      which channels composed of transmembrane connexin (Cx) or pannexin (Panx) 
      proteins can contribute. Multiple isoforms of both protein families are present 
      in the CNS and each CNS cell type is characterized by a unique Cx/Panx portfolio. 
      Over the last two decades, research has uncovered a multilevel platform via which 
      Cxs and Panxs can influence different cellular functions within a tissue: (1) Cx 
      GJCs enable a direct cell-cell communication of small molecules, (2) Cx 
      hemichannels and Panx channels can contribute to autocrine/paracrine signaling 
      pathways, and (3) different structural domains of these proteins allow for 
      channel-independent functions, such as cell-cell adhesion, interactions with the 
      cytoskeleton, and the activation of intracellular signaling pathways. In this 
      paper, we discuss current knowledge on their multifaceted contribution to brain 
      development and to specific processes in the NGVU, including synaptic 
      transmission and plasticity, glial signaling, vasomotor control, and blood-brain 
      barrier integrity in the mature CNS. By highlighting both physiological and 
      pathological conditions, it becomes evident that Cxs and Panxs can play a dual 
      role in the CNS and that an accurate fine-tuning of each signaling mechanism is 
      crucial for normal CNS physiology.
FAU - Decrock, Elke
AU  - Decrock E
AD  - Physiology Group, Department of Basic Medical Sciences, Ghent University, De 
      Pintelaan 185 (Block B, 3rd floor), 9000, Ghent, Belgium, elke.decrock@gmail.com.
FAU - De Bock, Marijke
AU  - De Bock M
FAU - Wang, Nan
AU  - Wang N
FAU - Bultynck, Geert
AU  - Bultynck G
FAU - Giaume, Christian
AU  - Giaume C
FAU - Naus, Christian C
AU  - Naus CC
FAU - Green, Colin R
AU  - Green CR
FAU - Leybaert, Luc
AU  - Leybaert L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150629
PL  - Switzerland
TA  - Cell Mol Life Sci
JT  - Cellular and molecular life sciences : CMLS
JID - 9705402
RN  - 0 (Connexins)
SB  - IM
MH  - Animals
MH  - Central Nervous System/metabolism/*pathology/*physiology
MH  - Connexins/*metabolism
MH  - Gap Junctions/metabolism/physiology
MH  - Humans
MH  - Nervous System Physiological Phenomena
MH  - Signal Transduction/*physiology
EDAT- 2015/06/30 06:00
MHDA- 2015/09/29 06:00
CRDT- 2015/06/30 06:00
PHST- 2015/06/05 00:00 [received]
PHST- 2015/06/11 00:00 [accepted]
PHST- 2015/06/30 06:00 [entrez]
PHST- 2015/06/30 06:00 [pubmed]
PHST- 2015/09/29 06:00 [medline]
AID - 10.1007/s00018-015-1962-7 [doi]
PST - ppublish
SO  - Cell Mol Life Sci. 2015 Aug;72(15):2823-51. doi: 10.1007/s00018-015-1962-7. Epub 
      2015 Jun 29.