PMID- 26119399
OWN - NLM
STAT- MEDLINE
DCOM- 20160404
LR  - 20181202
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 228
IP  - 3
DP  - 2015 Aug 30
TI  - Resequencing of early growth response 2 (EGR2) gene revealed a recurrent 
      patient-specific mutation in schizophrenia.
PG  - 958-60
LID - S0165-1781(15)00310-8 [pii]
LID - 10.1016/j.psychres.2015.05.035 [doi]
AB  - Abnormal myelination is considered as part of the pathophysiology of 
      schizophrenia. We resequenced the genomic DNA of the EGR2, which has a specific 
      function in the myelination of peripheral nervous system, in 543 schizophrenic 
      patients and 554 non-psychotic controls. We identified six known SNPs, which were 
      not associated with schizophrenia. Nevertheless, we discovered 24 rare mutations, 
      some of them were patient-specific, including a recurrent mutation 
      (p.P173_Y174insP), which might be associated with the pathogenesis of 
      schizophrenia.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Hu, Tsung-Ming
AU  - Hu TM
AD  - Department of Psychiatry, Yuli Mental Health Research Center, Yuli Branch, Taipei 
      Veterans General Hospital, Hualien, Taiwan.
FAU - Chen, Chia-Hsiang
AU  - Chen CH
AD  - Department of Psychiatry, Chang Gung Memorial Hospital at Linkou and Department 
      and Graduate School of Biomedical Sciences Chang Gung University, Taoyuan, 
      Taiwan.
FAU - Chuang, Yang-An
AU  - Chuang YA
AD  - Department of Psychiatry, Yuli Mental Health Research Center, Yuli Branch, Taipei 
      Veterans General Hospital, Hualien, Taiwan.
FAU - Hsu, Shih-Hsin
AU  - Hsu SH
AD  - Department of Psychiatry, Yuli Mental Health Research Center, Yuli Branch, Taipei 
      Veterans General Hospital, Hualien, Taiwan.
FAU - Cheng, Min-Chih
AU  - Cheng MC
AD  - Department of Psychiatry, Yuli Mental Health Research Center, Yuli Branch, Taipei 
      Veterans General Hospital, Hualien, Taiwan; Center for General Education, St. 
      Mary׳s Junior College of Medicine, Nursing and Management, Yilan County, Taiwan. 
      Electronic address: uncle055@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150606
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (EGR2 protein, human)
RN  - 0 (Early Growth Response Protein 2)
SB  - IM
MH  - Adult
MH  - DNA-Binding Proteins/genetics
MH  - Early Growth Response Protein 2/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mutation/*genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Schizophrenia/*diagnosis/*genetics
MH  - Sequence Analysis, DNA/*methods
OTO - NOTNLM
OT  - EGR2
OT  - Rare mutation
OT  - Schizophrenia
EDAT- 2015/06/30 06:00
MHDA- 2016/04/05 06:00
CRDT- 2015/06/30 06:00
PHST- 2015/03/02 00:00 [received]
PHST- 2015/05/18 00:00 [revised]
PHST- 2015/05/28 00:00 [accepted]
PHST- 2015/06/30 06:00 [entrez]
PHST- 2015/06/30 06:00 [pubmed]
PHST- 2016/04/05 06:00 [medline]
AID - S0165-1781(15)00310-8 [pii]
AID - 10.1016/j.psychres.2015.05.035 [doi]
PST - ppublish
SO  - Psychiatry Res. 2015 Aug 30;228(3):958-60. doi: 10.1016/j.psychres.2015.05.035. 
      Epub 2015 Jun 6.