PMID- 26120527
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2197-0378 (Print)
IS  - 2197-0378 (Electronic)
IS  - 2197-0378 (Linking)
VI  - 23
IP  - 5
DP  - 2014
TI  - Benefits and limitations of molecular diagnostics in peanut allergy: Part 14 of 
      the series Molecular Allergology.
PG  - 158-163
AB  - Allergic reactions to peanut (Arachis hypogaea, Ara h) are caused by 
      immunoglobulin E (IgE)-mediated sensitizations to various proteins. The stability 
      and relative proportion of these proteins in peanut determine the risk of 
      hazardous reactions. Hazardous sensitization to seed storage proteins [S2 
      albumins (Ara h 2, 6 and 7) > other seed storage proteins (Ara 1 and 3) > 
      oleosins (Ara h 10 and 11)] are distinct from sensitizations to lipid transfer 
      protein (Ara h 9) with moderate risk or cross-sensitizations to Bet v 
      1-homologous PR-10 protein (Ara h 8) and to profilin (Ara h 5) with low risk. A 
      specific IgE test, e.g. to Ara h 2 in the case of suspected systemic reaction, or 
      where this should be ruled out, can facilitate easier risk assessment. Results, 
      however, are only relevant in the presence of corresponding clinical symptoms. 
      IgE sensitization to peanut extract without hazardous reactions is often caused 
      in this part of the world by Bet v 1-related cross reactions (in birch pollen 
      allergy sufferers), cross-reactive carbohydrate determinants (CCD) or profilin 
      sensitizations. In the case of doubt, clinical relevance can only be established 
      by means of oral challenge, particularly since not all peanut allergens (e. g., 
      oleosins) are available as yet for diagnostic purposes.
FAU - Lange, Lars
AU  - Lange L
AD  - Department of Pediatrics, St. Marien-Hospital, Robert-Koch-Str. 1, 53115 Bonn, 
      Germany.
FAU - Beyer, Kirsten
AU  - Beyer K
AD  - Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin 
      Berlin, Berlin, Germany.
FAU - Kleine-Tebbe, Jorg
AU  - Kleine-Tebbe J
AD  - Allergy and Asthma Center Westend, Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140807
PL  - Germany
TA  - Allergo J Int
JT  - Allergo journal international
JID - 101659261
PMC - PMC4479434
OTO - NOTNLM
OT  - Ara h 2
OT  - Food allergy
OT  - IgE
OT  - cross reactivity
OT  - molecular diagnostics
OT  - oral challenge test
OT  - peanut
OT  - storage proteins
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
PMCR- 2015/06/24
CRDT- 2015/06/30 06:00
PHST- 2014/05/06 00:00 [received]
PHST- 2014/05/29 00:00 [accepted]
PHST- 2015/06/30 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PHST- 2015/06/24 00:00 [pmc-release]
AID - 19 [pii]
AID - 10.1007/s40629-014-0019-z [doi]
PST - ppublish
SO  - Allergo J Int. 2014;23(5):158-163. doi: 10.1007/s40629-014-0019-z. Epub 2014 Aug 
      7.