PMID- 26120528
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 2197-0378 (Print)
IS  - 2197-0378 (Electronic)
IS  - 2197-0378 (Linking)
VI  - 23
IP  - 5
DP  - 2014
TI  - Cellular in vitro diagnosis of adverse drug reactions.
PG  - 164-171
AB  - Adverse drug reactions can manifest clinically in a variety of ways. Whilst the 
      majority can be explained by dose-dependent side effects, there is group of 
      unpredictable immunological or non-immunological intolerances that represent a 
      particular diagnostic challenge. Skin tests are frequently negative, whilst 
      challenge tests are time-consuming and often hazardous. Against this backdrop, 
      cellular in vitro tests play a particularly important role in the identification 
      of the causative drug. Whilst basophil tests can be used in the case of 
      immunoglobulin E (IgE)- as well as non-IgE-mediated hypersensitivity reactions, 
      T-cellular test methods assist in the diagnosis of drug eruptions. The 
      reliability of individual tests can be affected by a variety of parameters, such 
      as the pathomechanism underlying the drug reaction, the causative medication, or 
      the point in time of testing. Not only is a sound knowledge of the basic 
      principles of the individual assays an essential prerequisite for correctly 
      indicating and interpreting this test method, but also an awareness of these 
      additional factors.
FAU - Mobs, Christian
AU  - Mobs C
AD  - Department of Dermatology and Allergology, Allergy Center Hessen, Philipps 
      University Marburg, Marburg, Germany.
FAU - Pfutzner, Wolfgang
AU  - Pfutzner W
AD  - Department of Dermatology and Allergology, Allergy Center Hessen, Philipps 
      University Marburg, Marburg, Germany ; Clinical & Experimental Allergy, Allergy 
      Center Hessen, Department of Dermatology and Allergology, Philipps-University 
      Marburg, Baldingerstrasse, 35043 Marburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140807
PL  - Germany
TA  - Allergo J Int
JT  - Allergo journal international
JID - 101659261
PMC - PMC4479488
OTO - NOTNLM
OT  - Basophils
OT  - Drug allergy
OT  - In vitro tests
OT  - T-lymphocytes
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
PMCR- 2015/06/24
CRDT- 2015/06/30 06:00
PHST- 2014/01/14 00:00 [received]
PHST- 2014/05/08 00:00 [accepted]
PHST- 2015/06/30 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PHST- 2015/06/24 00:00 [pmc-release]
AID - 20 [pii]
AID - 10.1007/s40629-014-0020-6 [doi]
PST - ppublish
SO  - Allergo J Int. 2014;23(5):164-171. doi: 10.1007/s40629-014-0020-6. Epub 2014 Aug 
      7.