PMID- 26121457
OWN - NLM
STAT- MEDLINE
DCOM- 20160815
LR  - 20210204
IS  - 1530-891X (Print)
IS  - 1530-891X (Linking)
VI  - 21
IP  - 9
DP  - 2015 Sep
TI  - HLA DQ2 HAPLOTYPE, EARLY ONSET OF GRAVES DISEASE, AND POSITIVE FAMILY HISTORY OF 
      AUTOIMMUNE DISORDERS ARE RISK FACTORS FOR DEVELOPING CELIAC DISEASE IN PATIENTS 
      WITH GRAVES DISEASE.
PG  - 993-1000
LID - 10.4158/EP15700.OR [doi]
AB  - OBJECTIVE: The diagnosis of celiac disease (CD) in patients with different 
      autoimmune diseases including Graves disease (GD) remains a challenge. The aims 
      of our study were to: (1) assess the prevalence of CD in Polish patients with GD 
      and (2) evaluate the prevalence of CD in the subgroups of patients with GD 
      divided on the basis of clinical and human leukocyte antigen (HLA) typing 
      criteria. METHODS: The prospective study was conducted at an academic referral 
      center. The study groups consisted of consecutive, euthyroid patients with GD (n 
      = 232) and healthy volunteers without autoimmune thyroid diseases (n = 122). The 
      diagnosis of CD was based on elevated immunoglobulin A autoantibodies to the 
      enzyme tissue transglutaminase (IgA-TTG) and small intestine biopsy findings. 
      RESULTS: CD was diagnosed in 8 patients with GD (3.4%) and 1 healthy volunteer 
      (0.8%). The development of CD in patients with GD was strongly associated with 
      HLA-DQ2 haplotype (as predicted from linkage disequilibria, 14.6% vs. 1.5%, P = 
      .009; odds ratio [OR] = 11.3; 95% confidence interval [CI] 1.3-252.7): 6 patients 
      with CD carried HLA-DRB1(*)03, 1 carried an HLA-DRB1(*)04 allele, and 1 had an 
      HLA-DRB1(*)07/(*)11 genotype. Multivariate analysis showed independent 
      associations between CD and early GD onset (P = .014, OR = 9.6), autoimmunity in 
      family (P = .029, OR = 6.3) and gastroenterologic symptoms (P = .031, OR = 8.1). 
      CONCLUSIONS: The results of our study suggest that serologic screening for CD may 
      be considered in GD patients (1) with the HLA alleles typical for CD, (2) with an 
      early onset of GD, or (3) a family history of autoimmunity. Moreover, the 
      diagnosis of CD should be explored in euthyroid GD patients with nonspecific 
      gastrointestinal symptoms.
FAU - Miskiewicz, Piotr
AU  - Miskiewicz P
FAU - Gos-Zajac, Agata
AU  - Gos-Zajac A
FAU - Kurylowicz, Alina
AU  - Kurylowicz A
FAU - Plazinska, Teresa Maria
AU  - Plazinska TM
FAU - Franaszczyk, Maria
AU  - Franaszczyk M
FAU - Bartoszewicz, Zbigniew
AU  - Bartoszewicz Z
FAU - Kondracka, Agnieszka
AU  - Kondracka A
FAU - Pirko-Kotela, Katarzyna
AU  - Pirko-Kotela K
FAU - Rupinski, Maciej
AU  - Rupinski M
FAU - Jarosz, Dorota
AU  - Jarosz D
FAU - Regula, Jaroslaw
AU  - Regula J
FAU - Ploski, Rafal
AU  - Ploski R
FAU - Bednarczuk, Tomasz
AU  - Bednarczuk T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150629
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Autoimmune Diseases/*genetics
MH  - Celiac Disease/complications/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Graves Disease/complications/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
EDAT- 2015/06/30 06:00
MHDA- 2016/08/16 06:00
CRDT- 2015/06/30 06:00
PHST- 2015/06/30 06:00 [entrez]
PHST- 2015/06/30 06:00 [pubmed]
PHST- 2016/08/16 06:00 [medline]
AID - S1530-891X(20)35731-1 [pii]
AID - 10.4158/EP15700.OR [doi]
PST - ppublish
SO  - Endocr Pract. 2015 Sep;21(9):993-1000. doi: 10.4158/EP15700.OR. Epub 2015 Jun 29.