PMID- 26122290
OWN - NLM
STAT- MEDLINE
DCOM- 20160406
LR  - 20181202
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Linking)
VI  - 73
DP  - 2015 Jul
TI  - Neuropeptide Y administration reverses tricyclic antidepressant 
      treatment-resistant depression induced by ACTH in mice.
PG  - 56-63
LID - S0018-506X(15)00109-9 [pii]
LID - 10.1016/j.yhbeh.2015.05.018 [doi]
AB  - Depression is one of the most common mental disorders and a primary cause of 
      disability. To better treat patients suffering this illness, elucidation of the 
      underlying psychopathological and neurobiological mechanisms is urgently needed. 
      Based on the above-mentioned evidence, we sought to investigate the effects of 
      neuropeptide Y (NPY) treatment in tricyclic antidepressant treatment-resistant 
      depression induced by adrenocorticotropic hormone (ACTH) administration. Mice 
      were treated with NPY (5.84, 11.7 or 23.4mmol/mul) intracerebroventricularly 
      (i.c.v.) for one or five days. The levels of serum corticosterone, tryptophan 
      (TRP), kynurenine (KYN), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), 
      brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and 
      indoleamine 2,3-dioxygenase (IDO) activity in the hippocampus were analyzed. The 
      behavioral parameters (depressive-like and locomotor activity) were also 
      verified. This study demonstrated that ACTH administration increased serum 
      corticosterone levels, KYN, 5-HIAA levels, IDO activity (hippocampus), immobility 
      in the forced swimming test (FST) and the latency to feed in the novelty 
      suppressed feeding test (NSFT). In addition, ACTH administration decreased the 
      BDNF and NGF levels in the hippocampus of mice. NPY treatment was effective in 
      preventing these hormonal, neurochemical and behavioral alterations. It is 
      suggested that the main target of NPY is the modulation of corticosterone and 
      neuronal plasticity protein levels, which may be closely linked with 
      pharmacological action in a model of tricyclic antidepressant treatment-resistant 
      depression. Thus, this study demonstrated a protective effect of NPY on the 
      alterations induced by ACTH administration in mice, indicating that it could be 
      useful as a therapy for the treatment of tricyclic antidepressant 
      treatment-resistant depression.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Antunes, Michelle S
AU  - Antunes MS
AD  - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas 
      Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000 Itaqui, 
      RS, Brazil.
FAU - Ruff, Jossana Rodrigues
AU  - Ruff JR
AD  - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas 
      Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000 Itaqui, 
      RS, Brazil.
FAU - de Oliveira Espinosa, Dieniffer
AU  - de Oliveira Espinosa D
AD  - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas 
      Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000 Itaqui, 
      RS, Brazil.
FAU - Piegas, Manuela Bastos
AU  - Piegas MB
AD  - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas 
      Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000 Itaqui, 
      RS, Brazil.
FAU - de Brito, Maicon Lenon Otenio
AU  - de Brito ML
AD  - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas 
      Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000 Itaqui, 
      RS, Brazil.
FAU - Rocha, Kellen Athaide
AU  - Rocha KA
AD  - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas 
      Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000 Itaqui, 
      RS, Brazil.
FAU - de Gomes, Marcelo Gomes
AU  - de Gomes MG
AD  - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas 
      Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000 Itaqui, 
      RS, Brazil.
FAU - Goes, Andre Tiago Rossito
AU  - Goes AT
AD  - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas 
      Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000 Itaqui, 
      RS, Brazil.
FAU - Souza, Leandro Cattelan
AU  - Souza LC
AD  - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas 
      Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000 Itaqui, 
      RS, Brazil.
FAU - Donato, Franciele
AU  - Donato F
AD  - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas 
      Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000 Itaqui, 
      RS, Brazil.
FAU - Boeira, Silvana Peterini
AU  - Boeira SP
AD  - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas 
      Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000 Itaqui, 
      RS, Brazil.
FAU - Jesse, Cristiano R
AU  - Jesse CR
AD  - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas 
      Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000 Itaqui, 
      RS, Brazil. Electronic address: cristianoricardojesse@yahoo.com.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150627
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Antidepressive Agents, Tricyclic)
RN  - 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase)
RN  - 0 (Neuropeptide Y)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - *Adrenocorticotropic Hormone
MH  - Animals
MH  - Antidepressive Agents, Tricyclic/*therapeutic use
MH  - Corticosterone/blood
MH  - Depressive Disorder/blood/*chemically induced/*drug therapy
MH  - Disease Models, Animal
MH  - Drug Resistance/*drug effects
MH  - Female
MH  - Hippocampus/drug effects/metabolism
MH  - Hydroxyindoleacetic Acid/blood
MH  - Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuropeptide Y/administration & dosage/*pharmacology
MH  - Swimming/physiology
OTO - NOTNLM
OT  - BDNF
OT  - Hypothalamic-pituitary-adrenocortical
OT  - Indoleamine 2,3-dioxygenase
OT  - Kynurenine
OT  - Neurotrophins
OT  - Serotonin
EDAT- 2015/07/01 06:00
MHDA- 2016/04/07 06:00
CRDT- 2015/07/01 06:00
PHST- 2014/06/27 00:00 [received]
PHST- 2015/05/19 00:00 [revised]
PHST- 2015/05/28 00:00 [accepted]
PHST- 2015/07/01 06:00 [entrez]
PHST- 2015/07/01 06:00 [pubmed]
PHST- 2016/04/07 06:00 [medline]
AID - S0018-506X(15)00109-9 [pii]
AID - 10.1016/j.yhbeh.2015.05.018 [doi]
PST - ppublish
SO  - Horm Behav. 2015 Jul;73:56-63. doi: 10.1016/j.yhbeh.2015.05.018. Epub 2015 Jun 
      27.