PMID- 26123355
OWN - NLM
STAT- MEDLINE
DCOM- 20151124
LR  - 20181113
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 195
IP  - 4
DP  - 2015 Aug 15
TI  - Opposing Roles of Dectin-1 Expressed on Human Plasmacytoid Dendritic Cells and 
      Myeloid Dendritic Cells in Th2 Polarization.
PG  - 1723-31
LID - 10.4049/jimmunol.1402276 [doi]
AB  - Dendritic cells (DCs) can induce and control host immune responses. DC 
      subset-dependent functional specialties and their ability to display functional 
      plasticity, which is mainly driven by signals via pattern recognition receptors, 
      identify DCs as immune orchestrators. A pattern recognition receptor, Dectin-1, 
      is expressed on myeloid DCs and known to play important roles in Th17 induction 
      and activation during fungal and certain bacterial infections. In this study, we 
      first demonstrate that human plasmacytoid DCs express Dectin-1 in both mRNA and 
      protein levels. More interestingly, Dectin-1-activated plasmacytoid DCs promote 
      Th2-type T cell responses, whereas Dectin-1-activated myeloid DCs decrease 
      Th2-type T cell responses. Such contrasting outcomes of Th2-type T cell responses 
      by the two DC subsets are mainly due to their distinct abilities to control 
      surface OX40L expression in response to beta-glucan. This study provides new 
      insights for the regulation of host immune responses by Dectin-1 expressed on 
      DCs.
CI  - Copyright (c) 2015 by The American Association of Immunologists, Inc.
FAU - Joo, HyeMee
AU  - Joo H
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204;
FAU - Upchurch, Katherine
AU  - Upchurch K
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204; Baylor University, 
      Institute for Biomedical Studies, Waco, TX 76706; and.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204;
FAU - Ni, Ling
AU  - Ni L
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204;
FAU - Li, Dapeng
AU  - Li D
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204;
FAU - Xue, Yaming
AU  - Xue Y
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204;
FAU - Li, Xiao-Hua
AU  - Li XH
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204;
FAU - Hori, Toshiyuki
AU  - Hori T
AD  - College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.
FAU - Zurawski, Sandra
AU  - Zurawski S
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204;
FAU - Liu, Yong-Jun
AU  - Liu YJ
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204;
FAU - Zurawski, Gerard
AU  - Zurawski G
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204; Baylor University, 
      Institute for Biomedical Studies, Waco, TX 76706; and.
FAU - Oh, SangKon
AU  - Oh S
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204; Baylor University, 
      Institute for Biomedical Studies, Waco, TX 76706; and sangkono@baylorhealth.edu.
LA  - eng
SI  - GENBANK/AF400595
SI  - GENBANK/AF400596
SI  - GENBANK/AF400597
SI  - GENBANK/AF400598
SI  - GENBANK/AF400599
SI  - GENBANK/AF400600
SI  - GENBANK/AF400601
SI  - GENBANK/AF400602
GR  - R21 AI101810/AI/NIAID NIH HHS/United States
GR  - U19 AI057234/AI/NIAID NIH HHS/United States
GR  - 1R21AI101810-01/AI/NIAID NIH HHS/United States
GR  - AI057234/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150629
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Cytokines)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Lectins, C-Type)
RN  - 0 (OX40 Ligand)
RN  - 0 (RNA, Messenger)
RN  - 0 (beta-Glucans)
RN  - 0 (dectin 1)
RN  - 37361-00-5 (beta-1,6-glucan)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (SYK protein, human)
RN  - EC 2.7.10.2 (Syk Kinase)
SB  - IM
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/immunology/*metabolism
MH  - *Gene Expression
MH  - Humans
MH  - Immunologic Memory
MH  - Influenza A virus/immunology
MH  - Intracellular Signaling Peptides and Proteins/metabolism
MH  - Lectins, C-Type/chemistry/*genetics/metabolism
MH  - Molecular Sequence Data
MH  - Myeloid Cells/immunology/*metabolism
MH  - OX40 Ligand/metabolism
MH  - Palatine Tonsil/cytology/immunology/metabolism
MH  - Protein Binding
MH  - Protein-Tyrosine Kinases/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Spleen/cytology/immunology/metabolism
MH  - Syk Kinase
MH  - T-Lymphocyte Subsets/immunology/metabolism
MH  - Th2 Cells/immunology/*metabolism
MH  - beta-Glucans/metabolism
PMC - PMC4530104
MID - NIHMS698296
EDAT- 2015/07/01 06:00
MHDA- 2015/12/15 06:00
PMCR- 2016/08/15
CRDT- 2015/07/01 06:00
PHST- 2014/09/05 00:00 [received]
PHST- 2015/06/02 00:00 [accepted]
PHST- 2015/07/01 06:00 [entrez]
PHST- 2015/07/01 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2016/08/15 00:00 [pmc-release]
AID - jimmunol.1402276 [pii]
AID - 10.4049/jimmunol.1402276 [doi]
PST - ppublish
SO  - J Immunol. 2015 Aug 15;195(4):1723-31. doi: 10.4049/jimmunol.1402276. Epub 2015 
      Jun 29.