PMID- 26123478
OWN - NLM
STAT- MEDLINE
DCOM- 20161024
LR  - 20161230
IS  - 1098-1101 (Electronic)
IS  - 0733-2459 (Linking)
VI  - 30
IP  - 6
DP  - 2015 Dec
TI  - Therapeutic plasma exchange as a therapeutic modality for the treatment of IVIG 
      complications.
PG  - 371-4
LID - 10.1002/jca.21386 [doi]
AB  - Intravenous immunoglobulin (IVIG) is used for the treatment of a number of 
      inflammatory conditions. Hemolysis due to passive transfer of blood group 
      antibodies is a well recognized complication of IVIG therapy. Therapy is largely 
      supportive and consists of blood product support and hemodialysis. We report the 
      use of therapeutic plasma exchange (TPE) as adjunct therapy for three patients 
      with complications attributed to IVIG. Two patients had hemolysis attributed to 
      IVIG; one patient was blood group A and the other blood group O. The third 
      patient was an orthotopic heart transplant recipient with a type A donor heart, 
      and anti-A antibodies detected after infusion of IVIG for suspected antibody 
      mediated rejection. Two patients had anti-A titers available that decreased after 
      initiation of plasma exchange. The blood group O patient with hemolysis had a 
      gradual stabilization of hemoglobin and resolution of the positive DAT. TPE may 
      be useful therapy for patients with severe hemolysis caused by IVIG or at risk 
      for tissue damage by blood group antibodies.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Welsh, Kerry J
AU  - Welsh KJ
AD  - Department of Pathology and Laboratory Medicine, University of Texas Health 
      Science Center at Houston, Houston, Texas.
FAU - Bai, Yu
AU  - Bai Y
AD  - Department of Pathology and Laboratory Medicine, University of Texas Health 
      Science Center at Houston, Houston, Texas.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150630
PL  - United States
TA  - J Clin Apher
JT  - Journal of clinical apheresis
JID - 8216305
RN  - 0 (ABO Blood-Group System)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - ABO Blood-Group System/immunology
MH  - Adult
MH  - Female
MH  - Heart Transplantation/adverse effects
MH  - Hemolysis/immunology
MH  - Humans
MH  - Immunization, Passive/adverse effects
MH  - Immunoglobulins, Intravenous/*adverse effects
MH  - Isoantibodies/adverse effects/blood
MH  - Male
MH  - Middle Aged
MH  - *Plasma Exchange
OTO - NOTNLM
OT  - IVIG
OT  - hemolysis
OT  - therapeutic plasma exchange
EDAT- 2015/07/01 06:00
MHDA- 2016/10/25 06:00
CRDT- 2015/07/01 06:00
PHST- 2014/05/11 00:00 [received]
PHST- 2014/08/29 00:00 [revised]
PHST- 2015/02/03 00:00 [accepted]
PHST- 2015/07/01 06:00 [entrez]
PHST- 2015/07/01 06:00 [pubmed]
PHST- 2016/10/25 06:00 [medline]
AID - 10.1002/jca.21386 [doi]
PST - ppublish
SO  - J Clin Apher. 2015 Dec;30(6):371-4. doi: 10.1002/jca.21386. Epub 2015 Jun 30.