PMID- 26123623
OWN - NLM
STAT- MEDLINE
DCOM- 20160628
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 Jun 30
TI  - Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated 
      with Risk of Periodontitis.
PG  - 11667
LID - 10.1038/srep11667 [doi]
LID - 11667
AB  - Matrix metalloproteinase-3 (MMP3) plays a key role in tissue degradation in 
      periodontitis. The relationship between the MMP3 -1171 5A/6A polymorphism 
      (rs35068180) and periodontitis has been widely studied. However, existing studies 
      have yielded contradictory results. We therefore conducted a meta-analysis to 
      comprehensively investigate these inconclusive findings. Several electronic 
      databases were searched for eligible articles. Seven case-control studies from 6 
      articles were searched without any language restrictions. Pooled estimates 
      indicated that MMP3 -1171 5A/6A polymorphism is associated with a decreased risk 
      of periodontitis (allelic genetic model: OR = 0.70, 95% CI: 0.62-0.80, 
      P(heterogeneity) = 0.315; heterozygous model: OR = 0.50, 95% CI: 0.39-0.65, 
      P(heterogeneity) = 0.221; homozygous model: OR = 0.42, 95% CI: 0.25-0.69, 
      P(heterogeneity) = 0.265; dominant model: OR = 0.49, 95% CI: 0.38-0.62, 
      P(heterogeneity) = 0.238, respectively). Similar results were also found in 
      chronic periodontitis (CP), Asian, Asian&CP, and non-smokers subgroups. Moreover, 
      MMP3 rs35068180 polymorphism might be associated with a lower risk of aggressive 
      periodontitis (AgP) in Asians (allelic genetic model: OR = 0.66, 95% CI: 
      0.48-0.91, P(heterogeneity) = 0.945), and CP in Caucasians and Brazilians. In 
      conclusion, this meta-analysis demonstrates that MMP3 -1171 5A/6A polymorphism 
      may be associated with decreased risk of both CP and AgP in Asians. Large 
      independent studies to replicate these results are necessary to validate these 
      associations in other populations.
FAU - Ding, Cheng
AU  - Ding C
AD  - Department of Stomatology, The Affiliated Hospital of Hangzhou Normal University, 
      Hangzhou, China.
FAU - Chen, Xing
AU  - Chen X
AD  - Department of Stomatology, The Affiliated Hospital of Hangzhou Normal University, 
      Hangzhou, China.
FAU - Zhang, Peng-tao
AU  - Zhang PT
AD  - Department of Stomatology, The Affiliated Hospital of Hangzhou Normal University, 
      Hangzhou, China.
FAU - Huang, Jin-ping
AU  - Huang JP
AD  - Physical Examination Center, The Affiliated Hospital of Hangzhou Normal 
      University, Hangzhou, China.
FAU - Xu, Yan
AU  - Xu Y
AD  - Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 
      China.
FAU - Chen, Ning
AU  - Chen N
AD  - Hangzhou Geriatric Hospital, Hangzhou, China.
FAU - Zhong, Liang-jun
AU  - Zhong LJ
AD  - 1] Department of Stomatology, The Affiliated Hospital of Hangzhou Normal 
      University, Hangzhou, China [2] School of Medicine, Hangzhou Normal University, 
      Hangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20150630
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Databases, Factual
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Odds Ratio
MH  - Periodontitis/*genetics/pathology
MH  - Polymorphism, Single Nucleotide
PMC - PMC4485030
EDAT- 2015/07/01 06:00
MHDA- 2016/06/29 06:00
PMCR- 2015/06/30
CRDT- 2015/07/01 06:00
PHST- 2015/01/08 00:00 [received]
PHST- 2015/06/01 00:00 [accepted]
PHST- 2015/07/01 06:00 [entrez]
PHST- 2015/07/01 06:00 [pubmed]
PHST- 2016/06/29 06:00 [medline]
PHST- 2015/06/30 00:00 [pmc-release]
AID - srep11667 [pii]
AID - 10.1038/srep11667 [doi]
PST - epublish
SO  - Sci Rep. 2015 Jun 30;5:11667. doi: 10.1038/srep11667.