PMID- 26124262
OWN - NLM
STAT- MEDLINE
DCOM- 20160211
LR  - 20221207
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Print)
IS  - 0194-5998 (Linking)
VI  - 153
IP  - 5
DP  - 2015 Nov
TI  - Change in Quality of Life with Velopharyngeal Insufficiency Surgery.
PG  - 857-64
LID - 10.1177/0194599815591159 [doi]
AB  - OBJECTIVES: (1) To define the minimal clinically important difference (MCID) of 
      the Velopharyngeal Insufficiency (VPI) Effects on Life Outcomes (VELO) 
      instrument, and (2) to test for the change in quality of life (QOL) after VPI 
      surgery. STUDY DESIGN: Prospective observational cohort. SETTING: VPI clinic at a 
      tertiary pediatric medical center. SUBJECTS AND METHODS: Children with VPI and 
      their parents completed the VELO instrument (higher score is better QOL) at 
      enrollment and then underwent VPI surgery (Furlow palatoplasty or sphincter 
      pharyngoplasty, n = 32), other treatments (obturator or oronasal fistula repair, 
      n = 7), or no treatment (n = 18). They completed the VELO instrument again and an 
      instrument of global rating of change in QOL at 1 year. The MCID was anchored to 
      the global change instrument scores corresponding to "a little" or "somewhat" 
      better. Within-group (paired t test) and between-group (Student t test) changes 
      in VELO scores were tested for the VPI surgery and no treatment groups. The 
      association between treatment group and change in VELO scores was tested with 
      multivariate linear regression, adjusting for confounders. RESULTS: Follow-up was 
      obtained for 37 of 57 (65%) patients. The mean (+/-standard deviation) change in 
      VELO scores corresponding to the MCID anchor was 15 +/- 13. The VELO score improved 
      significantly more in the VPI surgery group (change, 22 +/- 15; P < .001) than in 
      the no treatment group (change, 9 +/- 12; P = .04), after adjusting for confounders 
      (P = .007 between groups). CONCLUSION: VPI surgery using the Furlow palatoplasty 
      or sphincter pharyngoplasty improves VPI-specific QOL, and the improvement is 
      clinically important.
CI  - (c) American Academy of Otolaryngology-Head and Neck Surgery Foundation 2015.
FAU - Skirko, Jonathan R
AU  - Skirko JR
AD  - Department of Otolaryngology-Head & Neck Surgery, University of Washington, 
      Seattle, Washington, USA.
FAU - Weaver, Edward M
AU  - Weaver EM
AD  - Department of Otolaryngology-Head & Neck Surgery, University of Washington, 
      Seattle, Washington, USA.
FAU - Perkins, Jonathan A
AU  - Perkins JA
AD  - Department of Otolaryngology-Head & Neck Surgery, University of Washington, 
      Seattle, Washington, USA Division of Pediatric Otolaryngology-Head & Neck 
      Surgery, Seattle Children's Hospital, Seattle, Washington, USA Childhood 
      Communication Center, Seattle Children's Hospital, Seattle, Washington, USA.
FAU - Kinter, Sara
AU  - Kinter S
AD  - Speech and Language Services, Seattle Children's Hospital, Seattle, Washington, 
      USA.
FAU - Eblen, Linda
AU  - Eblen L
AD  - Speech and Language Services, Seattle Children's Hospital, Seattle, Washington, 
      USA.
FAU - Martina, Julie
AU  - Martina J
AD  - Speech and Language Services, Seattle Children's Hospital, Seattle, Washington, 
      USA.
FAU - Sie, Kathleen C Y
AU  - Sie KC
AD  - Department of Otolaryngology-Head & Neck Surgery, University of Washington, 
      Seattle, Washington, USA Division of Pediatric Otolaryngology-Head & Neck 
      Surgery, Seattle Children's Hospital, Seattle, Washington, USA Childhood 
      Communication Center, Seattle Children's Hospital, Seattle, Washington, USA 
      kathleen.sie@seattlechildrens.org.
LA  - eng
GR  - UL1TR000423/TR/NCATS NIH HHS/United States
GR  - R01 HL084139/HL/NHLBI NIH HHS/United States
GR  - T32 DC000018/DC/NIDCD NIH HHS/United States
GR  - UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - UL1 TR002319/TR/NCATS NIH HHS/United States
GR  - UL1 TR000423/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150629
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - Otorhinolaryngologic Surgical Procedures/*methods
MH  - Pharynx/*surgery
MH  - Postoperative Period
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Plastic Surgery Procedures/*methods
MH  - Treatment Outcome
MH  - Velopharyngeal Insufficiency/*psychology/surgery
MH  - Young Adult
PMC - PMC5940930
MID - NIHMS964586
OTO - NOTNLM
OT  - Furlow palatoplasty
OT  - minimal clinically important difference
OT  - minimal important change
OT  - quality of life
OT  - responsiveness
OT  - sphincter pharyngoplasty
OT  - velopharyngeal dysfunction
OT  - velopharyngeal insufficiency
EDAT- 2015/07/01 06:00
MHDA- 2016/02/13 06:00
PMCR- 2018/05/09
CRDT- 2015/07/01 06:00
PHST- 2014/09/28 00:00 [received]
PHST- 2015/05/22 00:00 [accepted]
PHST- 2015/07/01 06:00 [entrez]
PHST- 2015/07/01 06:00 [pubmed]
PHST- 2016/02/13 06:00 [medline]
PHST- 2018/05/09 00:00 [pmc-release]
AID - 0194599815591159 [pii]
AID - 10.1177/0194599815591159 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2015 Nov;153(5):857-64. doi: 
      10.1177/0194599815591159. Epub 2015 Jun 29.