PMID- 26124756
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150630
LR  - 20181113
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 6
DP  - 2015
TI  - The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of 
      Type 1 Diabetes and Other Autoimmune Diseases.
PG  - 288
LID - 10.3389/fimmu.2015.00288 [doi]
LID - 288
AB  - Dendritic cells (DCs) are key antigen-presenting cells that have an important 
      role in autoimmune pathogenesis. DCs control both steady-state T cell tolerance 
      and activation of pathogenic responses. The balance between these two outcomes 
      depends on several factors, including genetic susceptibility, environmental 
      signals that stimulate varied innate responses, and which DC subset is presenting 
      antigen. Although the specific DC phenotype can diverge depending on the tissue 
      location and context, there are four main subsets identified in both mouse and 
      human: conventional cDC1 and cDC2, plasmacytoid DCs, and monocyte-derived DCs. In 
      this review, we will discuss the role of these subsets in autoimmune pathogenesis 
      and regulation, as well as the genetic and environmental signals that influence 
      their function. Specific topics to be addressed include impact of susceptibility 
      loci on DC subsets, alterations in DC subset development, the role of infection- 
      and host-derived innate inflammatory signals, and the role of the intestinal 
      microbiota on DC phenotype. The effects of these various signals on disease 
      progression and the relative effects of DC subset composition and maturation 
      level of DCs will be examined. These areas will be explored using examples from 
      several autoimmune diseases but will focus mainly on type 1 diabetes.
FAU - Price, Jeffrey D
AU  - Price JD
AD  - Diabetes, Endocrinology, and Obesity Branch, Immune Tolerance Section, National 
      Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of 
      Health , Bethesda, MD , USA.
FAU - Tarbell, Kristin V
AU  - Tarbell KV
AD  - Diabetes, Endocrinology, and Obesity Branch, Immune Tolerance Section, National 
      Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of 
      Health , Bethesda, MD , USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150615
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC4466467
OTO - NOTNLM
OT  - T cell tolerance
OT  - antigen presentation
OT  - autoimmunity
OT  - dendritic cells
OT  - innate immunity
OT  - type 1 diabetes
EDAT- 2015/07/01 06:00
MHDA- 2015/07/01 06:01
PMCR- 2015/01/01
CRDT- 2015/07/01 06:00
PHST- 2015/04/10 00:00 [received]
PHST- 2015/05/18 00:00 [accepted]
PHST- 2015/07/01 06:00 [entrez]
PHST- 2015/07/01 06:00 [pubmed]
PHST- 2015/07/01 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2015.00288 [doi]
PST - epublish
SO  - Front Immunol. 2015 Jun 15;6:288. doi: 10.3389/fimmu.2015.00288. eCollection 
      2015.