PMID- 26124761
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150630
LR  - 20220408
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 6
DP  - 2015
TI  - Human and Mouse Mononuclear Phagocyte Networks: A Tale of Two Species?
PG  - 330
LID - 10.3389/fimmu.2015.00330 [doi]
LID - 330
AB  - Dendritic cells (DCs), monocytes, and macrophages are a heterogeneous population 
      of mononuclear phagocytes that are involved in antigen processing and 
      presentation to initiate and regulate immune responses to pathogens, vaccines, 
      tumor, and tolerance to self. In addition to their afferent sentinel function, 
      DCs and macrophages are also critical as effectors and coordinators of 
      inflammation and homeostasis in peripheral tissues. Harnessing DCs and 
      macrophages for therapeutic purposes has major implications for infectious 
      disease, vaccination, transplantation, tolerance induction, inflammation, and 
      cancer immunotherapy. There has been a paradigm shift in our understanding of the 
      developmental origin and function of the cellular constituents of the mononuclear 
      phagocyte system. Significant progress has been made in tandem in both human and 
      mouse mononuclear phagocyte biology. This progress has been accelerated by 
      comparative biology analysis between mouse and human, which has proved to be an 
      exceptionally fruitful strategy to harmonize findings across species. Such 
      analyses have provided unexpected insights and facilitated productive reciprocal 
      and iterative processes to inform our understanding of human and mouse 
      mononuclear phagocytes. In this review, we discuss the strategies, power, and 
      utility of comparative biology approaches to integrate recent advances in human 
      and mouse mononuclear phagocyte biology and its potential to drive forward 
      clinical translation of this knowledge. We also present a functional framework on 
      the parallel organization of human and mouse mononuclear phagocyte networks.
FAU - Reynolds, Gary
AU  - Reynolds G
AD  - Human Dendritic Cell Laboratory, Institute of Cellular Medicine, Newcastle 
      University , Newcastle upon Tyne , UK ; Musculoskeletal Research Group, Institute 
      of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
FAU - Haniffa, Muzlifah
AU  - Haniffa M
AD  - Human Dendritic Cell Laboratory, Institute of Cellular Medicine, Newcastle 
      University , Newcastle upon Tyne , UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150625
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC4479794
OTO - NOTNLM
OT  - comparative genomics
OT  - dendritic cells
OT  - macrophages
OT  - monocytes
OT  - mononuclear phagocyte system
EDAT- 2015/07/01 06:00
MHDA- 2015/07/01 06:01
PMCR- 2015/01/01
CRDT- 2015/07/01 06:00
PHST- 2015/05/11 00:00 [received]
PHST- 2015/06/12 00:00 [accepted]
PHST- 2015/07/01 06:00 [entrez]
PHST- 2015/07/01 06:00 [pubmed]
PHST- 2015/07/01 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2015.00330 [doi]
PST - epublish
SO  - Front Immunol. 2015 Jun 25;6:330. doi: 10.3389/fimmu.2015.00330. eCollection 
      2015.