PMID- 26124906
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150630
LR  - 20201001
IS  - 1918-3003 (Print)
IS  - 1918-3011 (Electronic)
IS  - 1918-3003 (Linking)
VI  - 7
IP  - 8
DP  - 2015 Aug
TI  - Factors Predicting Therapeutic Efficacy of Combination Treatment With Sitagliptin 
      and Insulin in Type 2 Diabetic Patients: The ASSIST-K Study.
PG  - 607-12
LID - 10.14740/jocmr2149w [doi]
AB  - BACKGROUND: It is unclear whether dipeptidyl peptidase-4 inhibitors decrease 
      hemoglobin A1c (HbA1c) in a glucose-dependent manner in patients on insulin 
      therapy who have impaired insulin secretion. This study investigated factors 
      influencing the efficacy of sitagliptin when used concomitantly with insulin to 
      treat type 2 diabetes mellitus (T2DM) in the real-world setting. METHODS: A 
      retrospective study was conducted of 1,004 T2DM patients at 36 Japanese clinics 
      associated with the Diabetes Task Force of the Kanagawa Physicians Association. 
      Eligible patients had been on insulin for at least 6 months, with a baseline 
      HbA1c of 7.0% (53 mmol/mol) or higher. Baseline characteristics and laboratory 
      data from 495 patients were subjected to multiple regression analysis to identify 
      factors influencing the change of HbA1c. RESULTS: Most patients (n = 809) 
      received sitagliptin at a dose of 50 mg. In the 1,004 patients, HbA1c decreased 
      by 0.74% (6 mmol/mol) and body weight increased by 0.1 kg after 6 months of 
      combination therapy. Multiple regression analysis showed that a higher baseline 
      HbA1c, older age, and lower body mass index influenced the change of HbA1c after 
      6 months. Hypoglycemic symptoms occurred in 7.4%, but none were severe. 
      CONCLUSIONS: These results emphasize the importance of a higher HbA1c at the 
      commencement of sitagliptin therapy in patients on insulin. Glucose-dependent 
      suppression of glucagon secretion by sitagliptin may be useful in patients with 
      impaired insulin secretion. Sitagliptin can be used concomitantly with insulin 
      irrespective of the insulin regimen, duration of insulin treatment, and 
      concomitant medications.
FAU - Ishikawa, Masashi
AU  - Ishikawa M
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Takai, Masahiko
AU  - Takai M
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Maeda, Hajime
AU  - Maeda H
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Kanamori, Akira
AU  - Kanamori A
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Kubota, Akira
AU  - Kubota A
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Amemiya, Hikaru
AU  - Amemiya H
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Iizuka, Takashi
AU  - Iizuka T
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Iemitsu, Kotaro
AU  - Iemitsu K
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Iwasaki, Tomoyuki
AU  - Iwasaki T
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Uehara, Goro
AU  - Uehara G
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Umezawa, Shinichi
AU  - Umezawa S
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Obana, Mitsuo
AU  - Obana M
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Kaneshige, Hideaki
AU  - Kaneshige H
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Kaneshiro, Mizuki
AU  - Kaneshiro M
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Kawata, Takehiro
AU  - Kawata T
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Sasai, Nobuo
AU  - Sasai N
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Saito, Tatsuya
AU  - Saito T
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Takuma, Tetsuo
AU  - Takuma T
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Takeda, Hiroshi
AU  - Takeda H
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Tanaka, Keiji
AU  - Tanaka K
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Tsurui, Nobuaki
AU  - Tsurui N
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Nakajima, Shigeru
AU  - Nakajima S
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Hoshino, Kazuhiko
AU  - Hoshino K
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Honda, Shin
AU  - Honda S
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Machimura, Hideo
AU  - Machimura H
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Matoba, Kiyokazu
AU  - Matoba K
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Minagawa, Fuyuki
AU  - Minagawa F
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Minami, Nobuaki
AU  - Minami N
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Miyairi, Yukiko
AU  - Miyairi Y
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Mokubo, Atsuko
AU  - Mokubo A
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Motomiya, Tetsuya
AU  - Motomiya T
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Waseda, Manabu
AU  - Waseda M
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Miyakawa, Masaaki
AU  - Miyakawa M
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Naka, Yoshikazu
AU  - Naka Y
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
FAU - Terauchi, Yasuo
AU  - Terauchi Y
AD  - Department of Endocrinology and Metabolism, Yokohama City University, 3-9 
      Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
FAU - Tanaka, Yasushi
AU  - Tanaka Y
AD  - Division of Metabolism and Endocrinology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki City, 
      Kanagawa 216-8511, Japan.
FAU - Matsuba, Ikuro
AU  - Matsuba I
AD  - The Study Group of the Diabetes Committee, Kanagawa Physicians Association, 3-1 
      Fujimi-cho, Naka-ku, Yokoyama City, Kanagawa 231-0037, Japan.
LA  - eng
PT  - Journal Article
DEP - 20150609
PL  - Canada
TA  - J Clin Med Res
JT  - Journal of clinical medicine research
JID - 101538301
PMC - PMC4471747
OTO - NOTNLM
OT  - Body weight
OT  - Combination therapy
OT  - HbA1c
OT  - Insulin
OT  - Multiple regression analysis
OT  - Sitagliptin
OT  - Type 2 diabetes
EDAT- 2015/07/01 06:00
MHDA- 2015/07/01 06:01
PMCR- 2015/06/09
CRDT- 2015/07/01 06:00
PHST- 2015/03/19 00:00 [accepted]
PHST- 2015/07/01 06:00 [entrez]
PHST- 2015/07/01 06:00 [pubmed]
PHST- 2015/07/01 06:01 [medline]
PHST- 2015/06/09 00:00 [pmc-release]
AID - 10.14740/jocmr2149w [doi]
PST - ppublish
SO  - J Clin Med Res. 2015 Aug;7(8):607-12. doi: 10.14740/jocmr2149w. Epub 2015 Jun 9.