PMID- 26125153
OWN - NLM
STAT- MEDLINE
DCOM- 20160301
LR  - 20181113
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 5
IP  - 6
DP  - 2015 Jun 30
TI  - The BDNF Val66Met polymorphism moderates the relationship between cognitive 
      reserve and executive function.
PG  - e590
LID - 10.1038/tp.2015.82 [doi]
AB  - The concept of cognitive reserve (CR) has been proposed to account for observed 
      discrepancies between pathology and its clinical manifestation due to underlying 
      differences in brain structure and function. In 433 healthy older adults 
      participating in the Tasmanian Healthy Brain Project, we investigated whether 
      common polymorphic variations in apolipoprotein E (APOE) or brain-derived 
      neurotrophic factor (BDNF) influenced the association between CR contributors and 
      cognitive function in older adults. We show that BDNF Val66Met moderates the 
      association between CR and executive function. CR accounted for 8.5% of the 
      variance in executive function in BDNF Val homozygotes, but CR was a 
      nonsignificant predictor in BDNF Met carriers. APOE polymorphisms were not linked 
      to the influence of CR on cognitive function. This result implicates BDNF in 
      having an important role in capacity for building or accessing CR.
FAU - Ward, D D
AU  - Ward DD
AD  - 1] School of Medicine, University of Tasmania, Hobart, TAS, Australia [2] Wicking 
      Dementia Research and Education Centre, University of Tasmania, Hobart, TAS, 
      Australia.
FAU - Summers, M J
AU  - Summers MJ
AD  - 1] Wicking Dementia Research and Education Centre, University of Tasmania, 
      Hobart, TAS, Australia [2] School of Social Sciences, University of the Sunshine 
      Coast, Sippy Downs, QLD, Australia.
FAU - Saunders, N L
AU  - Saunders NL
AD  - Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, 
      TAS, Australia.
FAU - Ritchie, K
AU  - Ritchie K
AD  - 1] Neuroepidemiology of Ageing Research Unit, Imperial College, London, UK [2] 
      Inserm, U1061 Neuropsychiatry, Montpellier, France.
FAU - Summers, J J
AU  - Summers JJ
AD  - 1] School of Medicine, University of Tasmania, Hobart, TAS, Australia [2] 
      Research Institute for Sport and Exercise Sciences, Liverpool John Moores 
      University, Liverpool, UK.
FAU - Vickers, J C
AU  - Vickers JC
AD  - 1] School of Medicine, University of Tasmania, Hobart, TAS, Australia [2] Wicking 
      Dementia Research and Education Centre, University of Tasmania, Hobart, TAS, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150630
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
RN  - 0 (Apolipoproteins E)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Apolipoproteins E/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cognition
MH  - *Cognitive Reserve
MH  - *Executive Function
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
PMC - PMC4490292
EDAT- 2015/07/01 06:00
MHDA- 2016/03/02 06:00
PMCR- 2015/06/01
CRDT- 2015/07/01 06:00
PHST- 2015/01/22 00:00 [received]
PHST- 2015/03/25 00:00 [revised]
PHST- 2015/05/21 00:00 [accepted]
PHST- 2015/07/01 06:00 [entrez]
PHST- 2015/07/01 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - tp201582 [pii]
AID - 10.1038/tp.2015.82 [doi]
PST - epublish
SO  - Transl Psychiatry. 2015 Jun 30;5(6):e590. doi: 10.1038/tp.2015.82.