PMID- 26125260
OWN - NLM
STAT- MEDLINE
DCOM- 20160516
LR  - 20190318
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 19
IP  - 11
DP  - 2015
TI  - Effect of 5-fluorouracil mobilized bone marrow regenerative cells transplantation 
      on brain injury following focal cerebral ischemia in rats.
PG  - 1994-2000
LID - 9026 [pii]
AB  - OBJECTIVE: The aim of this study was to evaluate the effect of 5-fluorouracil 
      mobilized bone marrow regenerative cells (BMRCs) transplantation on brain injury 
      following focal cerebral ischemia and to explore the mechanisms. MATERIALS AND 
      METHODS: Male Sprague-Dawley rats were subjected to middle cerebral artery 
      occlusion (MACO) for 120 minutes, followed by intravenous administration of 
      DAPI-labeled 1x10(7) 5-fluorouracil mobilized BMRCs at 24 h post MACO. Infarct 
      volumes, neurological deficit score, angiogenesis and cytokine expression were 
      evaluated at specific time point after cell transplantation. RESULTS: Comparable 
      number of BMRCs and bone marrow cells (BMCs) were found in the infarcted area at 
      Day 3 and Day 14 post MACO. Significant decreased infarcted size and neurological 
      deficit score were found in the animals receiving BMRCs. The microvessel density 
      was significantly increased after BMRCs transplantation. Moreover, the expression 
      of vessel endothelial growth factor (VEGF) was increased significantly after 
      BMRCs transplantation. CONCLUSIONS: Intravenous 5-fluorouracil mobilized BMRCs 
      were neuroprotective following MACO and might be considered as therapeutic choice 
      in the treatment of transient focal cerebral ischemia.
FAU - Xu, F-F
AU  - Xu FF
AD  - Department of Neurosurgery, No. 455 of The Chinese People's Liberation Army, 
      Shanghai, China. xuzhping@163.com.
FAU - Liu, X-L
AU  - Liu XL
FAU - Li, M
AU  - Li M
FAU - Yang, B
AU  - Yang B
FAU - Liao, H
AU  - Liao H
FAU - Xiao, L-H
AU  - Xiao LH
FAU - Xu, Z-P
AU  - Xu ZP
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Neuroprotective Agents)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
RIN - Eur Rev Med Pharmacol Sci. 2016;20(4):581. PMID: 26957255
MH  - Administration, Intravenous
MH  - Animals
MH  - Bone Marrow Cells/drug effects/metabolism
MH  - *Bone Marrow Transplantation
MH  - Brain Injuries/*drug therapy
MH  - Brain Ischemia/*drug therapy
MH  - Disease Models, Animal
MH  - Fluorouracil/*pharmacology
MH  - Infarction, Middle Cerebral Artery/drug therapy
MH  - Male
MH  - Neuroprotective Agents/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2015/07/01 06:00
MHDA- 2016/05/18 06:00
CRDT- 2015/07/01 06:00
PHST- 2015/07/01 06:00 [entrez]
PHST- 2015/07/01 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
AID - 9026 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2015;19(11):1994-2000.