PMID- 26125639
OWN - NLM
STAT- MEDLINE
DCOM- 20171016
LR  - 20171101
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 41
IP  - 4
DP  - 2016 Apr
TI  - Structural Changes in Pseudoexfoliation Syndrome Evaluated with Spectral Domain 
      Optical Coherence Tomography.
PG  - 513-20
LID - 10.3109/02713683.2015.1039651 [doi]
AB  - PURPOSE: To detect early structural changes of macular ganglion cell complex 
      (GCC), peripapillary nerve fiber layer (pNFL), and optic nerve head (ONH) 
      topography in subjects with pseudoexfoliation (PEX) using 3-D spectral domain 
      optical coherence tomography (SD-OCT, Topcon 3D-2000). MATERIALS AND METHODS: 
      Thirty-five participants with PEX and 29 healthy control subjects were included 
      in the study. All study participants underwent SD-OCT imaging. Macular NFL, 
      ganglion cell layer and inner plexiform layer (GCL + IPL), pNFL, and ONH 
      parameters were measured in each participant. The results were compared within 
      the two groups. RESULTS: In eyes with PEX, the superior and total mNFL thickness; 
      superior, and total GCL + IPL thickness; superior, inferior, and total GCC 
      thickness; and inferior, temporal, nasal, and total pNFL thickness were 
      significantly thinner than the control subjects. In the topographic evaluation of 
      ONH, there was no significant difference in optic disc area (ODA), cup area, rim 
      area, cup to disc ratio (CDR), cup volume, rim volume, linear CDR and vertical 
      CDR between the two groups. CONCLUSIONS: In PEX syndrome, similar decreases of 
      the GCC and NFL occurred, and a high correlation existed between the two. 
      Therefore, GCC can potentially be used to detect the early stages of PEX 
      glaucoma.
FAU - Eltutar, Kadir
AU  - Eltutar K
AD  - a Istanbul Research and Training Hospital , Istanbul , Turkey.
FAU - Acar, Fahrettin
AU  - Acar F
AD  - a Istanbul Research and Training Hospital , Istanbul , Turkey.
FAU - Kayaarasi Ozturker, Zeynep
AU  - Kayaarasi Ozturker Z
AD  - a Istanbul Research and Training Hospital , Istanbul , Turkey.
FAU - Unsal, Erkan
AU  - Unsal E
AD  - a Istanbul Research and Training Hospital , Istanbul , Turkey.
FAU - Ozdogan Erkul, Sezin
AU  - Ozdogan Erkul S
AD  - a Istanbul Research and Training Hospital , Istanbul , Turkey.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20150630
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
SB  - IM
MH  - Aged
MH  - Axial Length, Eye/*pathology
MH  - Cornea/*pathology
MH  - Exfoliation Syndrome/*diagnosis/physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - *Intraocular Pressure
MH  - Macula Lutea/pathology
MH  - Male
MH  - Nerve Fibers/pathology
MH  - Optic Disk/*pathology
MH  - Prospective Studies
MH  - ROC Curve
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Fields
OTO - NOTNLM
OT  - Optic nerve head
OT  - pseudoexfoliation syndrome
OT  - retinal ganglion cell complex
OT  - retinal nerve fiber layer
OT  - spectral-domain optical coherence tomography
EDAT- 2015/07/01 06:00
MHDA- 2017/10/17 06:00
CRDT- 2015/07/01 06:00
PHST- 2015/07/01 06:00 [entrez]
PHST- 2015/07/01 06:00 [pubmed]
PHST- 2017/10/17 06:00 [medline]
AID - 10.3109/02713683.2015.1039651 [doi]
PST - ppublish
SO  - Curr Eye Res. 2016 Apr;41(4):513-20. doi: 10.3109/02713683.2015.1039651. Epub 
      2015 Jun 30.