PMID- 26125747
OWN - NLM
STAT- MEDLINE
DCOM- 20160411
LR  - 20221207
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 2
DP  - 2015 May 25
TI  - Systematic meta-analysis of the association between monocyte chemoattractant 
      protein-1 -2518A/G polymorphism and risk of tuberculosis.
PG  - 5501-10
LID - 10.4238/2015.May.25.1 [doi]
AB  - Numerous studies have been conducted to investigate the association between 
      2518A/G polymorphisms in the monocyte chemoattractant protein-1 (MCP-1) gene and 
      the risk of tuberculosis (TB). However, the results have been inconsistent and 
      inconclusive. In this study, we performed a meta-analysis to evaluate the 
      association between the MCP-1 -2518A/G polymorphism and TB. The National Center 
      for Biotechnology Information Global Cross Database and Google Scholar database 
      were searched for relative studies. A total of 22 case-control studies that 
      included 7332 cases and 8004 controls for the -2518A/G single-nucleotide 
      polymorphism were identified. The results revealed an association between the 
      MCP-1 -2518A/G polymorphism and human TB susceptibility under a recessive model 
      (GG vs GA+AA), dominant model (GG+GA vs AA), and homozygote comparison (GG vs AA) 
      model for the entire database. For the dominant model, the overall odds ratio was 
      1.34 (95% confidence interval, 1.10-1.64, P = 0.004). For the recessive model, 
      the overall odds ratio was 1.46 (95% confidence interval, 1.15- 1.86, P = 0.002). 
      For the homozygote comparison, the overall odds ratio was 1.67 (95% confidence 
      interval, 1.20-2.32, P = 0.002). In the subgroup analysis by ethnicity, 
      significantly elevated risks were found in Asians and Americans, but not in 
      Africans and Europeans. We also used the Begg and Egger tests to examine 
      publication bias, and no major publication bias was detected. Our results 
      indicate that there is an association between the MCP-1 -2518A/G polymorphism and 
      human TB susceptibility.
FAU - Tian, G
AU  - Tian G
AD  - Pneumology Department, 263 Hospital of PLA, Beijing, China.
FAU - Li, X
AU  - Li X
AD  - Pneumology Department, 263 Hospital of PLA, Beijing, China.
FAU - Li, H
AU  - Li H
AD  - Internal Medicine, Forth Retirement Center of Combined Logistic Department of 
      Beijing Military Area Command, Beijing, China.
FAU - Wang, X
AU  - Wang X
AD  - Internal Medicine, Seventh Retirement Center of Tianjin Garrison Commands, 
      Tianjin, China.
FAU - Cheng, B
AU  - Cheng B
AD  - Anesthesia Department, Beijing Geriatric Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20150525
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Asian People/genetics
MH  - Chemokine CCL2/*genetics
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Tuberculosis/*genetics/pathology
MH  - White People
EDAT- 2015/07/01 06:00
MHDA- 2016/04/12 06:00
CRDT- 2015/07/01 06:00
PHST- 2015/07/01 06:00 [entrez]
PHST- 2015/07/01 06:00 [pubmed]
PHST- 2016/04/12 06:00 [medline]
AID - gmr4970 [pii]
AID - 10.4238/2015.May.25.1 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 May 25;14(2):5501-10. doi: 10.4238/2015.May.25.1.