PMID- 26125763
OWN - NLM
STAT- MEDLINE
DCOM- 20160411
LR  - 20221207
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 2
DP  - 2015 May 25
TI  - Human leukocyte antigen-B27 alleles in Xinjiang Uygur patients with ankylosing 
      spondylitis.
PG  - 5652-7
LID - 10.4238/2015.May.25.17 [doi]
AB  - We investigated the distribution of human leukocyte antigen (HLA)-B27 subtypes in 
      Uygur ankylosing spondylitis patients in Xinjiang. B27-positive patients with 
      ankylosing spondylitis were subtyped by using polymerase chain 
      reaction-sequence-based typing. The HLA-B27 subtype frequencies of Uygur patients 
      were compared with those in Han patients in Xinjiang and the other areas of 
      China. B*2705 was the predominant subtype in Uygur patients with a frequency of 
      58.95%, which was much higher than that in Han patients in Xinjiang (31.58%, P < 
      0.05) and the other areas of China (excluding the Shandong region, which was 
      63.89%). The frequency of B*2704 (27.37%) in Uygur patients was the lowest and 
      significantly lower than that in Han patients (61.18%, P < 0.05) and in 8 other 
      areas of China. B*2710 has not been previously reported in Uygur ankylosing 
      spondylitis patients; B*2704 was the main (61.18%) subtype in Han patients in 
      Xinjiang, followed by B*2705 (31.58%) and was similar to the characteristics of 
      Han patients in the other areas of China. B*2724 in Han ankylosing spondylitis 
      patients has not been previously reported. Additionally, the B*2702/B*2705 
      homozygote was identified in Uygur patients. B*2702/B*2704, B*2704/B*2705, and 
      B*2705/B*2705 homozygotes were identified in 3 Han patients. The distribution of 
      HLAB27 subtypes in Uygur ankylosing spondylitis patients in Xinjiang 
      significantly differed from that in Han patients. Understanding the distribution 
      of HLAB27 subtypes in ethnic minority populations of Xinjiang is important for 
      anthropological genetic studies and for analyzing the impact of genetic 
      background on ankylosing spondylitis susceptibility.
FAU - Zou, H-Y
AU  - Zou HY
AD  - Institute of Clinical Medicine, Urumqi General Hospital, Lanzhou Military Area 
      Command, Urumqi, Xinjiang, China.
FAU - Yu, W-Z
AU  - Yu WZ
AD  - Institute of Clinical Medicine, Urumqi General Hospital, Lanzhou Military Area 
      Command, Urumqi, Xinjiang, China.
FAU - Wang, Z
AU  - Wang Z
AD  - Institute of Clinical Medicine, Urumqi General Hospital, Lanzhou Military Area 
      Command, Urumqi, Xinjiang, China.
FAU - He, J
AU  - He J
AD  - Institute of Clinical Medicine, Urumqi General Hospital, Lanzhou Military Area 
      Command, Urumqi, Xinjiang, China.
FAU - Jiao, M
AU  - Jiao M
AD  - Institute of Clinical Medicine, Urumqi General Hospital, Lanzhou Military Area 
      Command, Urumqi, Xinjiang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150525
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/genetics
MH  - China
MH  - Ethnicity
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Spondylitis, Ankylosing/*genetics/pathology
EDAT- 2015/07/01 06:00
MHDA- 2016/04/12 06:00
CRDT- 2015/07/01 06:00
PHST- 2015/07/01 06:00 [entrez]
PHST- 2015/07/01 06:00 [pubmed]
PHST- 2016/04/12 06:00 [medline]
AID - gmr5305 [pii]
AID - 10.4238/2015.May.25.17 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 May 25;14(2):5652-7. doi: 10.4238/2015.May.25.17.