PMID- 26126194
OWN - NLM
STAT- MEDLINE
DCOM- 20151019
LR  - 20181202
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 20
IP  - 4
DP  - 2015 Aug
TI  - T-cell alloreactivity and transplantation outcome: a budding role for 
      heterologous immunity?
PG  - 454-60
LID - 10.1097/MOT.0000000000000218 [doi]
AB  - PURPOSE OF REVIEW: Despite the association between alloreactive T cells and poor 
      graft survival, the mechanisms behind T-cell-mediated rejection are still under 
      investigation. In this review, we will discuss the latest insights into the 
      impact of T-cell alloreactivity on solid organ transplantation and hematopoietic 
      stem cell transplantation (HSCT), with special emphasis on the potential impact 
      of heterologous immunity. RECENT FINDINGS: A large part of the memory T-cell 
      repertoire is induced upon virus infections, and evidence for a role of T-cell 
      receptor cross-reactivity of virus-induced memory T cells against allogeneic 
      human leukocyte antigen (HLA) is accumulating in experimental and clinical solid 
      organ transplantation studies. In HSCT, strong alloreactive potential of naive T 
      cells causes concerns for graft-versus-host disease while additional HLA-DP 
      matching is suggested to prevent CD4 alloreactivity. Furthermore, virus-induced 
      memory T cells hamper mixed chimerism induction, pointing once more towards a 
      role for heterologous immunity. SUMMARY: Both memory and naive T cells contribute 
      to the alloimmune response after transplantation. Monitoring for T-cell 
      phenotypes could help predict rejection episodes and/or graft-versus-host 
      disease, allowing timely intervention. Tailoring donor lymphocyte infusions and 
      additional HLA matching could prevent strong alloreactivity in HSCT. Furthermore, 
      the potential role of heterologous immunity in T-cell alloreactivity and 
      transplantation is gaining interest.
FAU - van den Heuvel, Heleen
AU  - van den Heuvel H
AD  - Department of Immunohaematology and Blood Transfusion, Leiden University Medical 
      Center, Leiden, the Netherlands.
FAU - Heidt, Sebastiaan
AU  - Heidt S
FAU - Roelen, Dave L
AU  - Roelen DL
FAU - Claas, Frans H J
AU  - Claas FH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
SB  - IM
MH  - Animals
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - *Immunity, Heterologous
MH  - Immunologic Memory
MH  - Organ Transplantation/*adverse effects
MH  - T-Lymphocytes/*immunology
MH  - Treatment Outcome
EDAT- 2015/07/01 06:00
MHDA- 2015/10/20 06:00
CRDT- 2015/07/01 06:00
PHST- 2015/07/01 06:00 [entrez]
PHST- 2015/07/01 06:00 [pubmed]
PHST- 2015/10/20 06:00 [medline]
AID - 10.1097/MOT.0000000000000218 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2015 Aug;20(4):454-60. doi: 
      10.1097/MOT.0000000000000218.