PMID- 26126836
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20161230
IS  - 1872-7131 (Electronic)
IS  - 0387-7604 (Linking)
VI  - 38
IP  - 1
DP  - 2016 Jan
TI  - Narcolepsy in a three-year-old girl: A case report.
PG  - 139-41
LID - S0387-7604(15)00126-6 [pii]
LID - 10.1016/j.braindev.2015.06.003 [doi]
AB  - OBJECTIVE: Narcolepsy is characterized by excessive daytime somnolence associated 
      with sleep paralysis, hallucinations when falling asleep or awakening, and 
      cataplexy. Early recognition of pediatric narcolepsy is essential for growth and 
      development. We experienced a case of narcolepsy in a three-year-old girl. 
      METHODS: The patient underwent brain MRI and 24h video-electroencephalogram (EEG) 
      monitoring. Polysomnography (PSG) with multiple sleep latency test (MSLT) and 
      human leukocyte antigen (HLA) DQ typing was performed. RESULTS: The brain MRI was 
      normal. 24h video-EEG monitoring revealed no abnormal slow or epileptiform 
      discharge on interictal EEG, and no EEG change during tongue thrusting, dropping 
      head with laughter, or flopping down, which was consistent with cataplexy 
      associated with narcolepsy. A mean sleep latency of 2.5 min and four episodes of 
      sleep-onset REM periods in five naps were observed in PSG with MSLT. She was 
      positive in HLA-DQB1*0602. Based on these findings, she was diagnosed as 
      narcoleptic with cataplexy. CONCLUSION: The history, combined with PSG and MSLT, 
      was helpful in the diagnosis of narcolepsy. We report a case of early-onset 
      narcolepsy presenting with excessive sleepiness and cataplexy.
CI  - Copyright (c) 2015 The Japanese Society of Child Neurology. Published by Elsevier 
      B.V. All rights reserved.
FAU - Park, Eu Gene
AU  - Park EG
AD  - Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Republic of Korea.
FAU - Lee, Jiwon
AU  - Lee J
AD  - Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Republic of Korea.
FAU - Joo, Eun Yeon
AU  - Joo EY
AD  - Department of Neurology, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Republic of Korea.
FAU - Lee, Munhyang
AU  - Lee M
AD  - Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Republic of Korea.
FAU - Lee, Jeehun
AU  - Lee J
AD  - Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Republic of Korea. Electronic address: jhlee0101@skku.edu.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150628
PL  - Netherlands
TA  - Brain Dev
JT  - Brain & development
JID - 7909235
SB  - IM
MH  - Brain/physiopathology
MH  - Child, Preschool
MH  - Diagnosis, Differential
MH  - Electroencephalography
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Narcolepsy/*diagnosis/genetics/*physiopathology/therapy
OTO - NOTNLM
OT  - Cataplexy
OT  - Narcolepsy
OT  - Toddler
EDAT- 2015/07/02 06:00
MHDA- 2016/10/07 06:00
CRDT- 2015/07/02 06:00
PHST- 2015/02/20 00:00 [received]
PHST- 2015/06/06 00:00 [revised]
PHST- 2015/06/22 00:00 [accepted]
PHST- 2015/07/02 06:00 [entrez]
PHST- 2015/07/02 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
AID - S0387-7604(15)00126-6 [pii]
AID - 10.1016/j.braindev.2015.06.003 [doi]
PST - ppublish
SO  - Brain Dev. 2016 Jan;38(1):139-41. doi: 10.1016/j.braindev.2015.06.003. Epub 2015 
      Jun 28.