PMID- 26130125
OWN - NLM
STAT- MEDLINE
DCOM- 20160721
LR  - 20200711
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 764
DP  - 2015 Oct 5
TI  - A comparative study on the cardioprotective potential of atorvastatin and 
      simvastatin in hyperhomocysteinemic rat hearts.
PG  - 48-54
LID - S0014-2999(15)30110-2 [pii]
LID - 10.1016/j.ejphar.2015.06.045 [doi]
AB  - The present study has been deliberated in order to compare the cardioprotective 
      potential of 3-hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors, 
      Atorvastatin and Simvastatin in hyperhomocysteinemic rat hearts. L-methionine 
      (1.7 g/kg/day orally) was administered to rats for 4 weeks to produce 
      experimental hyperhomocysteinemia (Hhcy). Isolated Langendorff-perfused normal 
      and hyperhomocysteinemic rat hearts were subjected to global ischemia for 30 min 
      followed by reperfusion for 120 min. The extent of myocardial damage was assessed 
      in terms of myocardial infarct size using triphenyltetrazolium chloride (TTC) 
      staining, and release of creatine kinase (CK) and lactate dehydrogenase (LDH) in 
      the coronary effluent; whereas the oxidative stress in the heart was assessed by 
      measuring lipid peroxidation, superoxide anion generation and reduced 
      glutathione. Ischemia-reperfusion (I/R) was noted to produce myocardial injury in 
      normal and hyperhomocysteinemic rat hearts, assessed in terms of increase in 
      myocardial infarct size, LDH and CK in coronary effluent and oxidative stress. 
      Treatment with Atorvatstain (50 microM) and Simvastatin (10 microM) afforded 
      cardioprotection against I/R-induced myocardial injury in normal and 
      hyperhomocysteinemic rat hearts as assessed in terms of reductions in myocardial 
      infarct size, LDH and CK levels in coronary effluent and oxidative stress. It may 
      be concluded that reductions in the high degree of oxidative stress may be 
      responsible for the observed cardioprotective potential of Atorva-and 
      Simvastatin, and both statins can be used interchangeably to afford 
      cardioprotection against I/R-induced myocardial injury in normal and 
      hyperhomocysteinemic rat hearts.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Rohilla, Ankur
AU  - Rohilla A
AD  - Department of Pharmacy, NIMS University, Shobha Nagar, Jaipur 303121, Rajasthan, 
      India. Electronic address: ankurrohilla1984@gmail.com.
FAU - Ahmad, Ayaz
AU  - Ahmad A
AD  - Department of Pharmacy, NIMS University, Shobha Nagar, Jaipur 303121, Rajasthan, 
      India.
FAU - Khan, M U
AU  - Khan MU
AD  - Sri Sai College of Pharmacy, Badhani, Pathankot 145001, Punjab, India.
FAU - Khanam, Razia
AU  - Khanam R
AD  - Faculty of Pharmacy, Jamia Hamdard University, Delhi 110062, India.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20150628
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Cardiotonic Agents)
RN  - A0JWA85V8F (Atorvastatin)
RN  - AGG2FN16EV (Simvastatin)
SB  - IM
MH  - Animals
MH  - Atorvastatin/*pharmacology
MH  - Cardiotonic Agents/*pharmacology
MH  - Female
MH  - Hyperhomocysteinemia/complications/metabolism/*prevention & control
MH  - Male
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion Injury/complications
MH  - Simvastatin/*pharmacology
OTO - NOTNLM
OT  - Atorvastatin
OT  - Hyperhomocysteinemia
OT  - Oxidative stress
OT  - Simvastatin
EDAT- 2015/07/02 06:00
MHDA- 2016/07/22 06:00
CRDT- 2015/07/02 06:00
PHST- 2014/09/09 00:00 [received]
PHST- 2015/06/19 00:00 [revised]
PHST- 2015/06/23 00:00 [accepted]
PHST- 2015/07/02 06:00 [entrez]
PHST- 2015/07/02 06:00 [pubmed]
PHST- 2016/07/22 06:00 [medline]
AID - S0014-2999(15)30110-2 [pii]
AID - 10.1016/j.ejphar.2015.06.045 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2015 Oct 5;764:48-54. doi: 10.1016/j.ejphar.2015.06.045. Epub 
      2015 Jun 28.