PMID- 26130428
OWN - NLM
STAT- MEDLINE
DCOM- 20161221
LR  - 20181202
IS  - 1720-8319 (Electronic)
IS  - 1594-0667 (Linking)
VI  - 28
IP  - 2
DP  - 2016 Apr
TI  - Decreased serum level of HMGB1 and MyD88 during human aging progress in healthy 
      individuals.
PG  - 175-80
LID - 10.1007/s40520-015-0402-8 [doi]
AB  - AIMS: Previous studies have suggested that high mobility group box-1 protein 
      (HMGB1) binds to the toll-like receptor 4 (TLR4) signaling mediates the 
      progression of various inflammatory diseases. But the roles of HMGB1 and TLR4 in 
      aging remain poorly unknown. In this study, we aimed to investigate the serum 
      levels of HMGB1 and myeloid differentiation factor 88 (MyD88), which is one of 
      TLR4's intracellular adaptor proteins during human aging process and their 
      relevance with cathepsin B (CTSB). METHODS: This research was conducted using the 
      blood samples provided by healthy people (n = 90, 63 men and 27 women). Subjects 
      were subdivided into groups with respect to age: young (about 25 years old, 
      n = 30), middle age (about 40 years old, n = 30), and aged (above 65 years old, 
      n = 30). Altered serum levels of HMGB1, MyD88 and CTSB were measured using an 
      enzyme-linked immunosorbent assay. RESULTS: The serum levels of HMGB1 and MyD88 
      were significantly decreased in the aged group compared with those in the young 
      group. Linear regression analysis showed that HMGB1 and MyD88 positively 
      correlated with CTSB among the whole healthy people. A negative correlation was 
      determined between MyD88 and age. CONCLUSIONS: The serum levels of HMGB1 and 
      MyD88 significantly decreased with age. MyD88, but not HMGB1, was negatively 
      correlated with age.
FAU - Fu, Guo-Xiang
AU  - Fu GX
AD  - Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, No. 600, Yi Shan road, Shanghai, 200233, People's Republic of 
      China. fuguoxiang888@163.com.
FAU - Chen, Alex F
AU  - Chen AF
AD  - Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, 
      PA, 15213, USA.
FAU - Zhong, Yuan
AU  - Zhong Y
AD  - Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, No. 600, Yi Shan road, Shanghai, 200233, People's Republic of 
      China.
FAU - Zhao, Jian
AU  - Zhao J
AD  - Shanghai Sixth People's Hospital Jinshan Branch, No. 147 Health Road, Zhujing 
      Town, Jinshan District, Shanghai, 201500, People's Republic of China.
FAU - Gu, Ying-Jia
AU  - Gu YJ
AD  - Shanghai Sixth People's Hospital Jinshan Branch, No. 147 Health Road, Zhujing 
      Town, Jinshan District, Shanghai, 201500, People's Republic of China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20150701
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
RN  - 0 (HMGB1 Protein)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (Toll-Like Receptor 4)
RN  - EC 3.4.22.1 (Cathepsin B)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*physiology
MH  - Cathepsin B/*metabolism
MH  - Female
MH  - *HMGB1 Protein/blood/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Myeloid Differentiation Factor 88/blood/metabolism
MH  - Regression Analysis
MH  - Signal Transduction/physiology
MH  - *Toll-Like Receptor 4/blood/metabolism
OTO - NOTNLM
OT  - Aging
OT  - Cathepsin B
OT  - HMGB1
OT  - MyD88
EDAT- 2015/07/02 06:00
MHDA- 2016/12/22 06:00
CRDT- 2015/07/02 06:00
PHST- 2015/04/05 00:00 [received]
PHST- 2015/06/12 00:00 [accepted]
PHST- 2015/07/02 06:00 [entrez]
PHST- 2015/07/02 06:00 [pubmed]
PHST- 2016/12/22 06:00 [medline]
AID - 10.1007/s40520-015-0402-8 [pii]
AID - 10.1007/s40520-015-0402-8 [doi]
PST - ppublish
SO  - Aging Clin Exp Res. 2016 Apr;28(2):175-80. doi: 10.1007/s40520-015-0402-8. Epub 
      2015 Jul 1.