PMID- 26131056
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150701
LR  - 20220408
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 4
DP  - 2015
TI  - Serum glycated albumin is superior to hemoglobin A1c for correlating with HMGB1 
      in coronary artery disease with type 2 diabetic mellitus patients.
PG  - 4821-5
AB  - High mobility group box 1 protein (HMGB1) was significantly increased in coronary 
      artery disease (CAD) with type 2 diabetic mellitus (T2DM) patients. This study 
      was to investigate the relationship between average blood glucose level and HMGB1 
      level in CAD with T2DM patients. 164 CAD patients were divided into two groups: 
      CAD with T2DM patients group and CAD without T2DM patients group. Glycated 
      albumin (GA) and glycosylated hemoglobin A1c (HbA1c) and HMGB1 concentrations 
      were measured in CAD with T2DM patients. The fasting glucose levels, GA and HbA1c 
      levels were sinificantly increased in CAD with T2DM patients compared to those in 
      CAD without T2DM patients (all P<0.05). The hs-CRP levels in CAD with T2DM 
      patients were significantly higher than those in CAD without T2DM patients 
      (P<0.05). The HMGB1 levels in CAD with T2DM patients were also significantly 
      higher than those in CAD without T2DM patients (P<0.05). Both serum GA levels and 
      HbA1c levels were positively correlated with HMGB1 levels (n=84, r=0.512 and 
      r=0.402, both P<0.05). The present study showed that both serum GA levels and 
      HbA1c levels were positively related with HMGB1 levels in CAD with T2DM patients. 
      Increased blood glucose levels may contribute to the increased HMGB1 levels. GA 
      level is superior to HbA1c level for correlating with HMGB1 level.
FAU - Yin, Jianjun
AU  - Yin J
AD  - Department of Radiology, Huangshi Central Hospital, Affiliated Hospital of Hubei 
      Polytechnic University Huangshi, China ; Hubei Key Laboratory of Kidney Disease 
      Pathogensis and Intervention Hubei, China.
FAU - Jin, Daoqun
AU  - Jin D
AD  - Department of Cardiology, Huangshi Central Hospital, Affiliated Hospital of Hubei 
      Polytechnic University Huangshi, China ; Hubei Key Laboratory of Kidney Disease 
      Pathogensis and Intervention Hubei, China.
FAU - Wang, Hong
AU  - Wang H
AD  - Department of Radiology, Huangshi Central Hospital, Affiliated Hospital of Hubei 
      Polytechnic University Huangshi, China ; Hubei Key Laboratory of Kidney Disease 
      Pathogensis and Intervention Hubei, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150415
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4483900
OTO - NOTNLM
OT  - Coronary artery disease
OT  - glycated albumin
OT  - glycosylated hemoglobin A1c
OT  - high mobility group box 1 protein
OT  - type 2 diabetic mellitus
EDAT- 2015/07/02 06:00
MHDA- 2015/07/02 06:01
PMCR- 2015/04/15
CRDT- 2015/07/02 06:00
PHST- 2015/01/19 00:00 [received]
PHST- 2015/03/14 00:00 [accepted]
PHST- 2015/07/02 06:00 [entrez]
PHST- 2015/07/02 06:00 [pubmed]
PHST- 2015/07/02 06:01 [medline]
PHST- 2015/04/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Apr 15;8(4):4821-5. eCollection 2015.